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Metabolites
Special Issues
Metabolic Biomarkers and Nutrition in Degenerative Conditions and Gastrointestinal Cancer...
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Metabolic Biomarkers and Nutrition in Degenerative Conditions and Gastrointestinal Cancer Surgery

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1261

Special Issue Editors

Dr. Irene Lidoriki

E-Mail Website
Guest Editor
1. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
2. Department of Occupational Medicine, Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, USA
3. First Department of Surgery, Laikon Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece
Interests: clinical nutrition; oncology; gastrointestinal cancer surgery; gastric cancer surgery; public health; geriatrics
Dr. Dimitrios Schizas

E-Mail Website
Guest Editor
First Department of Surgery, Laikon Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece
Interests: gastrointestinal cancer; gastric cancer surgery; esophageal cancer surgery; pancreatic cancer surgery; oncology; nutrition
Special Issues, Collections and Topics in MDPI journals
Dr. Maximos Frountzas

E-Mail Website
Guest Editor
First Propaedeutic Department of Surgery, Hippocration General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece
Interests: gastrointestinal cancer; gastric cancer surgery; esophageal cancer surgery; pancreatic cancer surgery; oncology; nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic biomarkers have gained popularity in the study of degenerative diseases, encompassing conditions such as cardiovascular disease, cancer, Alzheimer's disease, and Parkinson's disease. The significance of various metabolic biomarkers, along with nutritional indices and nutritional status, cannot be overstated in the context of disease diagnosis, progression, personalized patient treatment, and prognosis. In the era of precision medicine and personalized nutrition, it is imperative to delve into the intricate relationship between metabolism, nutrition, and the management of degenerative diseases and gastrointestinal cancers, not only within clinical settings but also in the broader context of public health.

This Special Issue of Metabolites is dedicated to disseminating comprehensive reviews and original research articles that explore recent breakthroughs in the utilization of metabolic biomarkers and the role of nutrition in degenerative conditions and gastrointestinal cancer surgery. Contributions should accentuate the identification of predictive biomarkers, emphasize underlying molecular mechanisms, and elucidate the metabolic changes associated with these diseases. We also welcome scientific papers focusing on the impact of nutrition on disease prevention, diagnosis, and patient outcomes. By shedding light on the intersection of metabolic biomarkers and nutrition, this Special Issue aspires to enhance our scientific comprehension of these diseases and foster patient-centered strategies in the management of degenerative conditions and gastrointestinal cancers.

Dr. Irene Lidoriki
Dr. Dimitrios Schizas
Dr. Maximos Frountzas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • nutrition
  • metabolism
  • metabolomics
  • degenerative disease
  • Parkinson’s disease
  • Alzheimer’s disease
  • cardiovascular disease
  • gastrointestinal cancer surgery

Published Papers (1 paper)

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10 pages, 862 KiB  
Brief Report
Exploring the Role of GDF-15 in Inflammatory Bowel Disease: A Case-Controlled Study Comparing Crohn’s Disease and Ulcerative Colitis with Non-Inflammatory Controls
by Ondřej Kučerka, Marie Blahutová, Vít Kosek, Petra Mináriková, Jan M. Horáček, Petr Urbánek and Martin Malý
Metabolites 2024, 14(4), 185; https://doi.org/10.3390/metabo14040185 - 25 Mar 2024
Viewed by 938
Abstract
Inflammatory bowel disease, encompassing Crohn’s disease and ulcerative colitis, is a persistent immune-mediated inflammatory gastrointestinal disease. This study investigates the role of growth differentiation factor 15 in severe IBD cases, aiming to identify a reliable parameter to assess disease severity and monitor activity. [...] Read more.
Inflammatory bowel disease, encompassing Crohn’s disease and ulcerative colitis, is a persistent immune-mediated inflammatory gastrointestinal disease. This study investigates the role of growth differentiation factor 15 in severe IBD cases, aiming to identify a reliable parameter to assess disease severity and monitor activity. We analyzed plasma samples from 100 patients undergoing biologic therapy for severe IBD and 50 control subjects. Our analysis included evaluations of GDF-15 levels, inflammatory markers, and clinical features. We employed statistical methods such as the Mann–Whitney U test, ANOVA, and Spearman’s correlation for an in-depth analysis. Our results demonstrated consistently higher GDF-15 levels in patients with both Crohn’s disease and ulcerative colitis compared to the control group, irrespective of the biologic treatment received. The correlation analysis indicated significant relationships between GDF-15 levels, patient age, fibrinogen, and IL-6 levels. This study positions GDF-15 as a promising biomarker for severe IBD, with notable correlations with age and inflammatory markers. These findings underscore GDF-15’s potential in enhancing disease monitoring and management strategies in an IBD context and encourage further research to clarify GDF-15’s role in the IBD pathophysiology. Full article
(This article belongs to the Special Issue Metabolic Biomarkers and Nutrition in Degenerative Conditions and Gastrointestinal Cancer Surgery)
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