Marine Natural Products in Anti-obesity and Metabolic Syndrome

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 443

Special Issue Editor

College of Life Sciences, Qingdao University, Qingdao, China
Interests: nutrition; functional foods; lipids; peptides; metabolic syndrome

Special Issue Information

Dear Colleagues,

Metabolic syndrome (MS) is a collection of multiple risk factors for type 2 diabetes mellitus and cardiovascular disease, including obesity, insulin resistance, hyperglycemia, dyslipidemia, hypertension and hyperuricemia. It is not a disease but a common complex entity that represents a worldwide epidemic and major public health concern, affecting approximately 30% of adults globally. Currently, the accurate pathogenesis of MS is still unclear, with central obesity and insulin resistance playing critical roles in initiating and perpetuating its pathologic features. To date, lifestyle interventions are still the main therapeutic strategies for the treatment of MS. Nowadays, increasing evidence suggests that marine natural products have effective ameliorative effects on MS-related metabolic abnormalities, explain their emergence as a potential preventive strategy for the syndrome. For this Special Issue, we invite original research papers and reviews on the current knowledge of the protective effects of marine natural products on metabolic syndrome and related metabolic abnormalities.

Dr. Xiang Gao
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine natural products
  • metabolic syndrome
  • anti-obesity
  • cardiovascular disease
  • diabetes mellitus
  • dyslipidemia
  • hypertension

Published Papers (1 paper)

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Research

14 pages, 2861 KiB  
Article
Pinctada martensii Hydrolysate Modulates the Brain Neuropeptidome and Proteome in Diabetic (db/db) Mice via the Gut–Brain Axis
by Jiayun Li, Yijun Lv, Yuanqing Wei, Xinzhi Wang, Shenghan Yan, Binyuan Zhao, Jipeng Sun, Rui Liu and Yueyang Lai
Mar. Drugs 2024, 22(6), 249; https://doi.org/10.3390/md22060249 - 28 May 2024
Viewed by 151
Abstract
Pinctada martensii hydrolysate (PMH) has been proved to have the effect of ameliorating disorders of glucose and lipid metabolism in db/db mice, but the mechanism of its hyperglycemia effect is still unclear. Bacterial communities in fecal samples from a normal control group, a [...] Read more.
Pinctada martensii hydrolysate (PMH) has been proved to have the effect of ameliorating disorders of glucose and lipid metabolism in db/db mice, but the mechanism of its hyperglycemia effect is still unclear. Bacterial communities in fecal samples from a normal control group, a diabetic control group, and a PMH-treated diabetes mellitus type 2 (T2DM) group were analyzed by 16S gene sequencing. Nano LC-MS/MS was used to analyze mice neuropeptides and proteomes. The 16S rDNA sequencing results showed that PMH modulated the structure and composition of the gut microbiota and improved the structure and composition of Firmicutes and Bacteroidetes at the phylum level and Desulfovibrionaceae and Erysipelatoclostridiaceae at the family level. Furthermore, the expressions of functional proteins of the central nervous system, immune response-related protein, and proteins related to fatty acid oxidation in the brain disrupted by an abnormal diet were recovered by PMH. PMH regulates the brain neuropeptidome and proteome and further regulates blood glucose in diabetic mice through the gut–brain axis. PMH may be used as a prebiotic agent to attenuate T2DM, and target-specific microbial species may have unique therapeutic promise for metabolic diseases. Full article
(This article belongs to the Special Issue Marine Natural Products in Anti-obesity and Metabolic Syndrome)
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