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Marine Bioactive Substances for Metabolic Syndrome

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (15 January 2023) | Viewed by 2473

Special Issue Editor

Special Issue Information

Dear Colleagues,

Metabolic syndrome is a complex metabolic disorder syndrome with obesity (central obesity) or insulin resistance as the core indicators, combined with dyslipidemia (elevated triglyceride and decreased high-density lipoprotein cholesterol) and hypertension. Metabolic syndrome can cause varying degrees of damage to cardiovascular system, respiratory system, endocrine system, and immune system. According to statistics, the number of patients with metabolic syndrome in the world is more than 25%. The complex background mechanism of metabolic syndrome makes it very difficult to develop drugs to effectively prevent or treat metabolic syndrome. At present, the common drugs on the market are aimed at a single component of metabolic syndrome. However, the disadvantage of drug therapy is that the target is single and easy to cause side effects.

Marine bioactive substances are a dynamic and popular research field around the world, which have the characteristics of a novel structure and wide activity. They have become an important source for the development of new leading drugs for the treatment of human diseases. It is urgently needed to find bioactive components (polyphenols, polysaccharides, polypeptides, etc.) that can effectively interfere with metabolic syndrome from marine organisms.

Prof. Dr. Xuewu Zhang
Guest Editor

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Keywords

  • marine bioactive components
  • metabolic syndrome
  • obesity
  • diabetes
  • hypertension

Published Papers (1 paper)

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Research

16 pages, 1881 KiB  
Article
Freshwater Macroalgae, Oedogonium, Grown in Wastewater Reduce Diet-Induced Metabolic Syndrome in Rats
by Sunil K. Panchal, Naga K. R. Ghattamaneni, Marie Magnusson, Andrew Cole, David Roberts, Nicolas Neveux, Lindsay Brown and Nicholas A. Paul
Int. J. Mol. Sci. 2022, 23(22), 13811; https://doi.org/10.3390/ijms232213811 - 9 Nov 2022
Cited by 1 | Viewed by 2001
Abstract
Macroalgae produce compounds with industrial, pharmaceutical and nutritional applications. In this study, biomass from the freshwater macroalgal genus Oedogonium was grown in either treated municipal wastewater (M) or ash dam water from a coal-fired power station (D). The biomass was investigated for its [...] Read more.
Macroalgae produce compounds with industrial, pharmaceutical and nutritional applications. In this study, biomass from the freshwater macroalgal genus Oedogonium was grown in either treated municipal wastewater (M) or ash dam water from a coal-fired power station (D). The biomass was investigated for its metabolic responses in high-carbohydrate, high-fat diet-fed rats, a model of human metabolic syndrome. The Oedogonium biomass cultured in M contained higher amounts of K, Mg, omega-3 polyunsaturated fatty acids (PUFA), insoluble fibre and β-carotene, while biomass grown in D contained higher amounts of Al, Fe, V, Zn, Mn and As. Biomass from M further increased body weight and inflammation in the heart and colon in high-carbohydrate, high-fat diet-fed rats. In contrast, biomass from D prevented changes in metabolic, cardiovascular and liver parameters without changing tissue histology. We suggest that increased intake of metals and metalloids through macroalgal biomass from D may decrease abdominal fat deposition while polysaccharides, PUFA and carotenoids from M may improve blood glucose responses in an obesogenic diet. Thus, macroalgal biomass grown in different wastewater sources could be acceptable for feed or food applications. This biomass could even provide potential health benefits in diet-induced metabolic syndrome. Full article
(This article belongs to the Special Issue Marine Bioactive Substances for Metabolic Syndrome)
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