Adipose Tissue in Human Health and Disease 2.0

Dear Colleagues,

In recent years, our understanding of the role of adipose tissue in human health and disease has changed significantly. Currently, it is not only perceived as a store of energy but as an active endocrine organ that can modulate the functions of other tissues and systems. The obesity-related excessive accumulation of lipids causes changes in adipocyte metabolism, leading to, among other results, mitochondrial dysfunction and associated endoplasmic reticulum stress. As a result, the expression of many genes in adipocytes changes unfavorably; thus, the profile of substances secreted by adipose tissue (adipokines) does the same. This process, called adipose tissue dysfunction, is believed to underlie the development of chronic obesity complications, affecting virtually all organs and significantly impairing quality of life. The purpose of this Special Issue is to summarize contemporary research on the role of adipose tissue in the regulation of human physiology and the health consequences of obesity-related adipocyte dysfunction.

Prof. Dr. Alina Kuryłowicz
Guest Editor

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• adipose tissue
• metabolic inflammation
• insulin resistance
• obesity
• type 2 diabetes
• metabolic syndrome