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Cancers
Special Issues
Advanced Research on Spine Tumor
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Advanced Research on Spine Tumor

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 633

Special Issue Editor

Dr. Satoshi Kato

E-Mail Website
Guest Editor
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan
Interests: spine; spine tumor surgery; metastatic spine tumor; low back pain; ossified spinal ligament
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Despite advances in the treatment of primary and metastatic tumors, clinical outcomes are still unfavorable. The majority of primary tumors have a poor response rate to chemotherapy and conventional radiotherapy, and lack the feasibility of oncologically appropriate surgical resection. The skeleton is the third most common site of metastases after the lungs and liver, with the spine being the most frequently affected bone. Metastatic spinal tumors often result in severe pain and neurological symptoms, reducing the performance status (PS). In metastatic tumor patients, a decrease in PS not only directly affects mortality, but also affect it indirectly by preventing the application of effective systemic therapies. Clinicians have a number of issues that need to be resolved and improved in the management and treatment of spinal tumors.

This Special Issue of Cancers aims to highlight recent advanced research on spine tumor which can improve the understanding of different assessments and/or innovative and personalized treatments for the management of primary and metastatic spinal tumors. Authors are encouraged to submit their original research, including systematic reviews and meta-analyses, clinical trials, observational studies, case series study and experimental work which presents recent advances in the management and treatment of spinal tumors.

Dr. Satoshi Kato
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diagnosis
  • treatment strategy
  • prognostic factors and scoring systems
  • pain management
  • surgical techniques
  • spondylectomy/vertebrectomy
  • stereotactic body radiotherapy
  • particle beam radiation therapy
  • minimum invasive treatment

Published Papers (1 paper)

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Research

11 pages, 5946 KiB  
Article
Spinal Intradural Tumor Resection via Long-Segment Approaches and Clinical Long-Term Follow-Up
by Laura Dieringer, Lea Baumgart, Laura Schwieren, Jens Gempt, Maria Wostrack, Bernhard Meyer and Vicki M. Butenschoen
Cancers 2024, 16(9), 1782; https://doi.org/10.3390/cancers16091782 - 5 May 2024
Viewed by 514
Abstract
Introduction: Spinal intradural tumors account for 15% of all CNS tumors. Typical tumor entities include ependymomas, astrocytomas, meningiomas, and neurinomas. In cases of multiple affected segments, extensive approaches may be necessary to achieve the gold standard of complete tumor resection. Methods: We performed [...] Read more.
Introduction: Spinal intradural tumors account for 15% of all CNS tumors. Typical tumor entities include ependymomas, astrocytomas, meningiomas, and neurinomas. In cases of multiple affected segments, extensive approaches may be necessary to achieve the gold standard of complete tumor resection. Methods: We performed a bicentric, retrospective cohort study of all patients equal to or older than 14 years who underwent multi-segment surgical treatment for spinal intradural tumors between 2007 and 2023 with approaches longer than four segments without instrumentation. We assessed the surgical technique and the clinical outcome regarding signs of symptomatic spinal instability. Children were excluded from our cohort. Results: In total, we analyzed 33 patients with a median age of 44 years and interquartile range IQR of 30–56 years, including the following tumors: 21 ependymomas, one subependymoma–ependymoma mixed tumor, two meningiomas, two astrocytomas, and seven patients with other entities. The median length of the approach was five spinal segments with a range of 4–14 and with the foremost localization in the cervical or thoracic spine. Laminoplasty was the most chosen approach (72.2%). The median time to follow-up was 13 months IQR (4–56 months). Comparing pre- and post-surgery outcomes, 72.2% of the patients (n = 24) reported pain improvement after surgery. The median modified McCormick scores pre- and post surgery were equal to II IQR (I–II) and II IQR (I–III), respectively. Discussion: We achieved satisfying results with long-segment approaches. In general, patients reported pain improvement after surgery and received similar low modified McCormick scores pre- and post surgery and did not undergo secondary dorsal fixation. Thus, we conclude that intradural tumor resection via extensive approaches does not seem to impair long-term spinal stability in our cohort. Full article
(This article belongs to the Special Issue Advanced Research on Spine Tumor)
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