Nanomaterial-Based Biosensors to Support the One Health Concept

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: 15 August 2024 | Viewed by 4192

Special Issue Editors

Laboratory of Advanced Micro- and Nanodiagnostics (AMINO), Institute for Global Food Security, School of Biological Sciences, QUB, 19 Chlorine Gardens, Belfast BT9 5DL, UK
Interests: optical-active nanomaterials for biosensing; nanoplasmonics-based biosensing platforms; point-of-care diagnostics
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Guest Editor
Institute for Global Food Security, School of Biological Sciences, Queen’s University, Belfast BT9 5DL, UK
Interests: food safety; food fraud and food integrity
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Guest Editor
International Iberian Nanotechnology Laboratory, Braga, Portugal
Interests: food safety; food quality; nanosensors; food authenticity; micro total analysis systems (uTAS)

Special Issue Information

Dear Colleagues,

Access to sufficient, safe and nutritious food is one of the basic human needs in order to maintain a healthy and active life. Over the past century, the quality of life has been considerably increased around the world. We are healthier, richer, safer, and live longer than ever before. However, there is a downside to this success. Recent food adulteration scandals have affected consumer trust, and clearly alert us of the risks associated with possible contaminations at any points in the food value chain. We have also witnessed a dramatic increase in foodborne and infectious diseases due to the fast-growing worldwide trade in livestock, food products in combination with the increase in human mobility. Due to their rapid proliferation, single viruses or bacteria can result in a pandemic and cause millions of deaths and enormous economic losses—the COVID-19 pandemic is a vivid example. Therefore, it is important to ask how we can effectively manage and control foodborne outbreaks at their first onset. How can we ensure that food products produced locally or imported are genuine, safe, and of acceptable quality to consumers? These questions are being asked by more people, more frequently, and are among the world’s remaining grand challenges.

With their extremely small size and unique optical, electrical, and catalytic properties, nanomaterials can offer opportunities to develop biosensor platforms which can provide the sensitive, low-cost, rapid, and on-site detection of not only animal and plant diseases but also environmental conditions, thus providing us with better approaches to control and prevent diseases, economic loss, and adverse impact to our health. This Special Issue of Biosensors will be devoted to bringing together review and original research articles discussing nanomaterials-based biosensors for the detection of not only food contaminants but also animal and plant diseases as well as environmental conditions that directly or indirectly impact human health through the food chain. We cordially invite scientists working in different disciplines to submit their work for this Special Issue. Potential topics include, but are not limited to, nanomaterials-based biosensors for:

  • The detection and identification of biological and chemical contaminants in foods and feeds, and in the environment;
  • Monitoring the health of farming animals;
  • Monitoring the quality, integrity, and safety conditions of food during production, transportation, and storage.

Dr. Cuong Cao
Prof. Dr. Christopher Elliott
Dr. Marta Prado
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • nanosensors
  • food analysis
  • nanofabrication
  • microfabrication
  • lab-on-chip
  • nanomaterials

Published Papers (2 papers)

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Research

13 pages, 4288 KiB  
Article
Ti3C2 Nanosheets Functionalized with Ferritin–Biomimetic Platinum Nanoparticles for Electrochemical Biosensors of Nitrite
by Rongqiu Mu, Danzhu Zhu and Gang Wei
Biosensors 2024, 14(5), 258; https://doi.org/10.3390/bios14050258 - 19 May 2024
Cited by 1 | Viewed by 501
Abstract
Nitrites widely exist in human life and the natural environment, but excessive contents of nitrites will result in adverse effects on the environment and human health; hence, sensitive and stable nitrite detection systems are needed. In this study, we report the synthesis of [...] Read more.
Nitrites widely exist in human life and the natural environment, but excessive contents of nitrites will result in adverse effects on the environment and human health; hence, sensitive and stable nitrite detection systems are needed. In this study, we report the synthesis of Ti3C2 nanosheets functionalized with apoferritin (ApoF)–biomimetic platinum (Pt) nanoparticle (Pt@ApoF/Ti3C2) composite materials, which were formed by using ApoF as a template and protein-inspired biomineralization. The formed nanohybrid exhibits excellent electrochemical sensing performance towards nitrite (NaNO2). Specifically, the Pt@ApoF catalyzes the conversion of nitrites into nitrates, converting the chemical signal into an electrical signal. The prepared Pt@ApoF/Ti3C2-based electrochemical NaNO2 biosensors demonstrate a wide detection range of 0.001–9 mM with a low detection limit of 0.425 μM. Additionally, the biosensors possess high selectivity and sensitivity while maintaining a relatively stable electrochemical sensing performance within 7 days, enabling the monitoring of NaNO2 in complex environments. The successful preparation of the Pt@ApoF/Ti3C2 nanohybrid materials provides a new approach for constructing efficient electrochemical biosensors, offering a simple and rapid method for detecting NaNO2 in complex environments. Full article
(This article belongs to the Special Issue Nanomaterial-Based Biosensors to Support the One Health Concept)
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13 pages, 2682 KiB  
Article
One-Pot CRISPR-Cas12a-Based Viral DNA Detection via HRP-Enriched Extended ssDNA-Modified Au@Fe3O4 Nanoparticles
by Dong Hyeok Park, Izzati Haizan, Min Ju Ahn, Min Yu Choi, Min Jung Kim and Jin-Ha Choi
Biosensors 2024, 14(1), 26; https://doi.org/10.3390/bios14010026 - 2 Jan 2024
Cited by 1 | Viewed by 1449
Abstract
In the context of virus outbreaks, the need for early and accurate diagnosis has become increasingly urgent. In addition to being crucial for effective disease control, timely and precise detection of viral infections is also necessary for the implementation of essential public health [...] Read more.
In the context of virus outbreaks, the need for early and accurate diagnosis has become increasingly urgent. In addition to being crucial for effective disease control, timely and precise detection of viral infections is also necessary for the implementation of essential public health measures, especially during pandemics. Among these measures, point-of-care testing (POCT) stands out as a powerful approach with the potential to revolutionize the landscape of viral diagnosis. In this study, we developed a one-pot clustered regularly interspaced short palindromic repeats (CRISPR)-Cas12a-based viral DNA detection system tailored for POCT; this method utilizes multi-enzyme-modified Au@Fe3O4 nanoparticles. As an alternative to nucleic acid amplification, our method uses single-stranded DNA elongation to facilitate multi-enzyme modification; this guarantees heightened sensitivity and expedites the diagnostic process. We achieved a satisfactory limit of detection of 0.25 nM, demonstrating the remarkable sensitivity of the method without the need for sophisticated equipment. The incorporation of Au@Fe3O4 magnetic nanoparticles facilitates sample separation, further streamlining the workflow and reinforcing the simplicity of our method. This integrated approach offers a practical solution for sensitive viral DNA detection in POCT scenarios, advancing the field of rapid and accurate diagnostics. Full article
(This article belongs to the Special Issue Nanomaterial-Based Biosensors to Support the One Health Concept)
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