Adenylate Cyclases of Trypanosoma brucei, Environmental Sensors and Controllers of Host Innate Immune Response
Abstract
:1. Introduction
2. Role of cAMP in Innate and Adaptive Immunity and Pathogen Strategies to Counteract Immunity
3. T. brucei cAMP Signaling Pathway: From an Environmental Sensing Mechanism to an Innate Immune Evasion System
3.1. Receptor-Type ACs, a Hallmark of Trypanosomatids
3.2. cAMP Signal Integration in the T. brucei Flagellum, a Complex Organ for Sensing the Environment
3.3. Intracellular cAMP Function and a Novel cAMP Pathway in T. brucei
3.4. Role of ESAG4, a Receptor-Type AC Specific for the Bloodstream Form
3.5. Trypanosomal ACs as a Tolerogenic Tool in Mammalian Host Innate Immunity
4. Concluding Remarks and Perspectives
Acknowledgments
Conflicts of Interest
References
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Salmon, D. Adenylate Cyclases of Trypanosoma brucei, Environmental Sensors and Controllers of Host Innate Immune Response. Pathogens 2018, 7, 48. https://doi.org/10.3390/pathogens7020048
Salmon D. Adenylate Cyclases of Trypanosoma brucei, Environmental Sensors and Controllers of Host Innate Immune Response. Pathogens. 2018; 7(2):48. https://doi.org/10.3390/pathogens7020048
Chicago/Turabian StyleSalmon, Didier. 2018. "Adenylate Cyclases of Trypanosoma brucei, Environmental Sensors and Controllers of Host Innate Immune Response" Pathogens 7, no. 2: 48. https://doi.org/10.3390/pathogens7020048