An in-shoe pressure measurement (IPM) system can be used to measure center of pressure (COP) locations, and has fewer restrictions compared to the more conventional approach using a force platform. The insole of an IPM system, however, has its own coordinate system. To use an IPM system along with a motion capture system, there is thus a need to align the coordinate systems of the two measurement systems. To address this need, the current study examined two different approaches—rigid body transformation and nonlinear mapping (i.e., multilayer feed-forward neural network (MFNN))—to express COP measurements from an IPM system in the coordinate system of a motion capture system. Ten participants (five male and five female) completed several simulated manual material handling (MMH) activities, and during these activities the performance of the two approaches was assessed. Results indicated that: (1) performance varied between MMH activity types; and (2) a MFNN performed better than or comparable to the rigid body transformation, depending on the specific input variable sets used. Further, based on the results obtained, it was argued that a nonlinear mapping vs. rigid body transformation approach may be more effective to account for shoe deformation during MMH or potentially other types of physical activity. Full article