Precise duplication of the genome is a prerequisite for the health and longevity of multicellular organisms. The temporal regulation of origin specification, replication licensing, and firing at replication origins is mediated by the cyclin-dependent kinases. Here the role of Cip1 interacting Zinc finger protein 1 (Ciz1) in regulation of cell cycle progression is discussed. Ciz1 contributes to regulation of the G1/S transition in mammalian cells. Ciz1 contacts the pre-replication complex (pre-RC) through cell division cycle 6 (Cdc6) interactions and aids localization of cyclin A- cyclin-dependent kinase 2 (CDK2) activity to chromatin and the nuclear matrix during initiation of DNA replication. We discuss evidence that Ciz1 serves as a kinase sensor that regulates both initiation of DNA replication and prevention of re-replication. Finally, the emerging role for Ciz1 in cancer biology is discussed. Ciz1 is overexpressed in common tumors and tumor growth is dependent on Ciz1 expression, suggesting that Ciz1 is a driver of tumor growth. We present evidence that Ciz1 may contribute to deregulation of the cell cycle due to its ability to alter the CDK activity thresholds that are permissive for initiation of DNA replication. We propose that Ciz1 may contribute to oncogenesis by induction of DNA replication stress and that Ciz1 may be a multifaceted target in cancer therapy. Full article

Within the Reducing Emissions from Deforestation and Degradation (REDD+) framework, the involvement of local communities in national forest monitoring activities has the potential to enhance monitoring efficiency at lower costs while simultaneously promoting transparency and better forest management. We assessed the consistency of forest monitoring data (mostly activity data related to forest change) collected by local experts in the UNESCO Kafa Biosphere Reserve, Ethiopia. Professional ground measurements and high resolution satellite images were used as validation data to assess over 700 forest change observations collected by the local experts. Furthermore, we examined the complementary use of local datasets and remote sensing by assessing spatial, temporal and thematic data quality factors. Based on this complementarity, we propose a framework to integrate local expert monitoring data with satellite-based monitoring data into a National Forest Monitoring System (NFMS) in support of REDD+ Measuring, Reporting and Verifying (MRV) and near real-time forest change monitoring. Full article