In the tumor microenvironment hypoxia and nutrient deprived states can induce endoplasmic reticulum (ER) stress. If ER stress is not relieved, the tumor cells may become apoptotic. Therefore, targeting ER homeostasis is a potential strategy for cancer treatment. Various chemotherapeutic agents including histone deacetylase (HDAC) inhibitors can induce ER stress to cause cell death in cancers. Some HDAC inhibitors can prevent HDAC from binding to the specificity protein 1-binding site of the promoter of reversion-inducing cysteine-rich protein with Kazal motifs (RECK) and up-regulate RECK expression. Up-regulation of RECK expression by HDAC inhibitors has been observed in various cancer types. RECK is a tumor and metastasis suppressor gene and is critical for regulating tumor cell invasiveness and metastasis. RECK also modulates ER stress via binding to and sequestering glucose-regulated protein 78 protein, so that the transmembrane sensors, such as protein kinase RNA-like ER kinase are released to activate eukaryotic translational initiation factor 2α phosphorylation and enhance ER stress. Therefore, HDAC inhibitors may directly induce ER stress or indirectly induce this stress by up-regulating RECK in cancer cells. Full article

Most bamboo forests grow in humid climates in low-latitude tropical or subtropical monsoon areas, and they are generally located in hilly areas. Bamboo trunks are very straight and smooth, which means that bamboo forests have low structural diversity. These features are beneficial to synthetic aperture radar (SAR) microwave penetration and they provide special information in SAR imagery. However, some factors (e.g., foreshortening) can compromise the interpretation of SAR imagery. The fusion of SAR and optical imagery is considered an effective method with which to obtain information on ground objects. However, most relevant research has been based on two types of remote sensing image. This paper proposes a new fusion scheme, which combines three types of image simultaneously, based on two fusion methods: bidimensional empirical mode decomposition (BEMD) and the Gram-Schmidt transform. The fusion of panchromatic and multispectral images based on the Gram-Schmidt transform can enhance spatial resolution while retaining multispectral information. BEMD is an adaptive decomposition method that has been applied widely in the analysis of nonlinear signals and to the nonstable signal of SAR. The fusion of SAR imagery with fused panchromatic and multispectral imagery using BEMD is based on the frequency information of the images. It was established that the proposed fusion scheme is an effective remote sensing image interpretation method, and that the value of entropy and the spatial frequency of the fused images were improved in comparison with other techniques such as the discrete wavelet, à-trous, and non-subsampled contourlet transform methods. Compared with the original image, information entropy of the fusion image based on BEMD improves about 0.13–0.38. Compared with the other three methods it improves about 0.06–0.12. The average gradient of BEMD is 4%–6% greater than for other methods. BEMD maintains spatial frequency 3.2–4.0 higher than other methods. The experimental results showed the proposed fusion scheme could improve the accuracy of bamboo forest classification. Accuracy increased by 12.1%, and inaccuracy was reduced by 11.0%. Full article

Traditional Chinese Medicine (TCM) has been used to treat diseases in China for thousands of years. TCM compositions are complex, using as their various sources plants, animals, fungi, and minerals. Polysaccharides are one of the active and important ingredients of TCMs. Polysaccharides from TCMs exhibit a wide range of biological activities in terms of immunity- modifying, antiviral, anti-inflammatory, anti-oxidative, and anti-tumor properties. With their widespread biological activities, polysaccharides consistently attract scientist's interests, and the studies often concentrate on the extraction, purification, and biological activity of TCM polysaccharides. Currently, numerous studies have shown that the modification of polysaccharides can heighten or change the biological activities, which is a new angle of polysaccharide research. This review highlights the current knowledge of TCM polysaccharides, including their extraction, purification, modification, and biological activity, which will hopefully provide profound insights facilitating further research and development. Full article

Reclamation of abandoned farmland is crucial to a sustainable agriculture in arid regions. This study aims to evaluate the impact of different reclamation treatments on abandoned salinized farmland. We investigated four artificial reclamation treatments, continuous cotton (CC), continuous alfalfa (CA), tree-wheat intercropping (TW) and trees (TS), which were conducted in 2011–2012 in the Manasi River Basin of Xinjiang Province, China. Soil nutrient, microorganism and enzyme activity were examined in comparison with natural succession (CK) in an integrated analysis on soil fertility improvement and soil salinization control with these reclamations. Results indicate that the four artificial reclamation treatments are more effective approaches than natural restoration to reclaim abandoned farmland. TW and CA significantly increased soil nutrient content compared to CK. CC reduced soil salinity to the lowest level among all treatments. TW significantly enhanced soil enzyme activity. All four artificial reclamations increased soil microbial populations and soil microbial biomass carbon. TW and CA had the greatest overall optimal effects among the four treatments in terms of the ecological outcomes. If both economic benefits and ecological effects are considered, TW would be the best reclamation mode. The findings from this study will assist in selecting a feasible method for reclamation of abandoned farmland for sustainable agriculture in arid regions. Full article

China’s rapid urbanization has contributed to a massive agricultural land loss that could threaten its food security. Timely and accurate mapping of urban expansion and urbanization-related agricultural land loss can provide viable measures to be taken for urban planning and agricultural land protection. In this study, urban expansion in China from 2001 to 2013 was mapped using the nighttime stable light (NSL), normalized difference vegetation index (NDVI), and water body data. Urbanization-related agricultural land loss during this time period was then evaluated at national, regional, and metropolitan scales by integrating multiple sources of geographic data. The results revealed that China’s total urban area increased from 31,076 km² in 2001 to 80,887 km² in 2013, with an average annual growth rate of 13.36%. This widespread urban expansion consumed 33,080 km² of agricultural land during this period. At a regional scale, the eastern region lost 18,542 km² or 1.2% of its total agricultural land area. At a metropolitan scale, the Shanghai–Nanjing–Hangzhou (SNH) and Pearl River Delta (PRD) areas underwent high levels of agricultural land loss with a decrease of 6.12% (4728 km²) and 6.05% (2702 km²) of their total agricultural land areas, respectively. Special attention should be paid to the PRD, with a decline of 13.30% (1843 km²) of its cropland. Effective policies and strategies should be implemented to mitigate urbanization-related agricultural land loss in the context of China’s rapid urbanization. Full article

Monitoring the dynamics of surface water using remotely sensed data generally requires both high spatial and high temporal resolutions. One effective and popular approach for achieving this is image fusion. This study adopts a widely accepted fusion model, the Enhanced Spatial and Temporal Adaptive Reflectance Fusion Model (ESTARFM), for blending the newly available coarse-resolution Suomi NPP-VIIRS data with Landsat data in order to derive water maps at 30 m resolution. The Pan-sharpening technique was applied to preprocessing NPP-VIIRS data to achieve a higher-resolution before blending. The modified Normalized Difference Water Index (mNDWI) was employed for mapping surface water area. Two fusion alternatives, blend-then-index (BI) or index-then-blend (IB), were comparatively analyzed against a Landsat derived water map. A case study of mapping Poyang Lake in China, where water distribution pattern is complex and the water body changes frequently and drastically, was conducted. It has been revealed that the IB method derives more accurate results with less computation time than the BI method. The BI method generally underestimates water distribution, especially when the water area expands radically. The study has demonstrated the feasibility of blending NPP-VIIRS with Landsat for achieving surface water mapping at both high spatial and high temporal resolutions. It suggests that IB is superior to BI for water mapping in terms of efficiency and accuracy. The finding of this study also has important reference values for other blending works, such as image blending for vegetation cover monitoring. Full article

Urban flooding is a serious natural hazard to many cities all over the world, which has dramatic impacts on the urban environment and human life. Urban flooding mapping has practical significance for the prevention and management of urban flood disasters. Remote sensing images with high temporal resolutions are widely used for urban flooding mapping, but have a limitation of relatively low spatial resolutions. In this study, a new method based on a generalized regression neural network (GRNN) is proposed to achieve improved accuracy in super-resolution mapping of urban flooding (SMUF) from remote sensing images. The GRNN-SMUF algorithm was proposed and then assessed using Landsat 5 and Landsat 8 images of Brisbane city in Australia and Wuhan city in China. Compared to three traditional methods, GRNN-SMUF mapped urban flooding more accurately according to both visual and quantitative assessments. The results of this study will improve the accuracy of urban flooding mapping using easily-available remote sensing images with medium-low spatial resolutions and will be propitious to the prevention and management of urban flood disasters. Full article

Daily, or more frequent, maps of surface water have important applications in environmental and water resource management. In particular, surface water maps derived from remote sensing imagery play a useful role in the derivation of spatial inundation patterns over time. MODIS data provide the most realistic means to achieve this since they are daily, although they are often limited by cloud cover during flooding events, and their spatial resolutions (250–1000 m pixel) are not always suited to small river catchments. This paper tests the suitability of the MODIS sensor for identifying flood events through comparison with streamflow and rainfall measurements at a number of sites during the wet season in Northern Australia. This is done using the MODIS Open Water Likelihood (OWL) algorithm which estimates the water fraction within a pixel. On a temporal scale, cloud cover often inhibits the use of MODIS imagery at the start and lead-up to the peak of a flood event, but there are usually more cloud-free data to monitor the flood’s recession. Particularly for smaller flood events, the MODIS view angle, especially when the view angle is towards the sun, has a strong influence on total estimated flood extent. Our results showed that removing pixels containing less than 6% water can eliminate most commission errors when mapping surface water. The exception to this rule was for some spectrally dark pixels occurring along the edge of the MODIS swath where the relative azimuth angle (i.e., angle between the MODIS’ and sun’s azimuth angle) was low. Using only MODIS OWL pixels with a low view angle, or a range distance of less than 1000 km, also improves the results and minimizes multi-temporal errors in flood identification and extent. Given these limitations, MODIS OWL surface water maps are sensitive to the dynamics of water movement when compared to streamflow data and does appear to be a suitable product for the identification and mapping of inundation extent at large regional/basin scales. Full article

To move towards sustainable development, the mining industry needs to identify better mine water management practices for reducing raw water use, increasing water use efficiency, and eliminating environmental impacts in a precondition of securing mining production. However, the selection of optimal mine water management practices is technically challenging due to the lack of scientific tools to comprehensively evaluate management options against a set of conflicting criteria. This work has provided a solution to aid the identification of more sustainable mine water management practices. The solution includes a conceptual framework for forming a decision hierarchy; an evaluation method for assessing mine water management practices; and a sensitivity analysis in view of different preferences of stakeholders or managers. The solution is applied to a case study of the evaluation of sustainable water management practices in 16 mines located in the Bowen Basin in Queensland, Australia. The evaluation results illustrate the usefulness of the proposed solution. A sensitivity analysis is performed according to preference weights of stakeholders or managers. Some measures are provided for assessing sensitivity of strategy ranking outcomes if the weight of an indicator changes. Finally, some advice is given to improve the mine water management in some mines. Full article

Stroke is one of the leading causes of mortality, with a high incidence of severe morbidity in survivors. The treatment to minimize tissue injury after stroke is still unsatisfactory and it is mandatory to develop effective treatment strategies for stroke. The pathophysiology of ischemic stroke is complex and involves many processes including energy failure, loss of ion homeostasis, increased intracellular calcium level, platelet aggregation, production of reactive oxygen species, disruption of blood brain barrier, and inflammation and leukocyte infiltration, etc. Tetrandrine, a bisbenzylisoquinoline alkaloid, has many pharmacologic effects including anti-inflammatory and cytoprotective effects. In addition, tetrandrine has been found to protect the liver, heart, small bowel and brain from ischemia/reperfusion injury. It is a calcium channel blocker, and can inhibit lipid peroxidation, reduce generation of reactive oxygen species, suppress the production of cytokines and inflammatory mediators, inhibit neutrophil recruitment and platelet aggregation, which are all devastating factors during ischemia/reperfusion injury of the brain. Because tetrandrine can counteract these important pathophysiological processes of ischemic stroke, it has the potential to be a protective agent for ischemic stroke. Full article

A new anthraquinone, Rubiacordone A (1) (6-acetoxy-1-hydroxy-2-methylanthraquinone-3-O-α-L-rhamnopyranoside), was isolated together with the known anthraquinone, 1-acetoxy-6-hydroxy-2-methylanthraquinone-3-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside] (2), from the dried roots of Rubia cordifolia. Their structures were elucidated on the basis of extensive 1D and 2D-NMR, as well as HRESI-MS spectroscopic analysis. Metabolites 1 and 2 showed considerable antimicrobial activity against Gram-positive bacteria. Full article