Background: Inflammatory bowel disease (IBD) patients may be at risk of vitamin B12 and folate insufficiencies, as these micronutrients are absorbed in the small intestine, which is affected by IBD. However, a consensus has not been reached on the association between IBD and serum folate and vitamin B12 concentrations. Methods: In this study, a comprehensive search of multiple databases was performed to identify studies focused on the association between IBD and serum folate and vitamin B12 concentrations. Studies that compared serum folate and vitamin B12 concentrations between IBD and control patients were selected for inclusion in the meta-analysis. Results: The main outcome was the mean difference in serum folate and vitamin B12 concentrations between IBD and control patients. Our findings indicated that the average serum folate concentration in IBD patients was significantly lower than that in control patients, whereas the mean serum vitamin B12 concentration did not differ between IBD patients and controls. In addition, the average serum folate concentration in patients with ulcerative colitis (UC) but not Crohn’s disease (CD) was significantly lower than that in controls. This meta-analysis identified a significant relationship between low serum folate concentration and IBD. Conclusions: Our findings suggest IBD may be linked with folate deficiency, although the results do not indicate causation. Thus, providing supplements of folate and vitamin B12 to IBD patients may improve their nutritional status and prevent other diseases. Full article

The estimation of soil organic carbon (SOC) stock in terrestrial ecosystems of China is of particular importance because it exerts a major influence on worldwide terrestrial carbon (C) storage and global climate change. Map-based estimates of SOC stocks conducted in previous studies have typically been applied on planimetric areas, which led to the underestimation of SOC stock. In the present study, SOC stock in China was estimated using a revised method on three-dimensional (3-D) surfaces, which considered the undulation of the landforms. Data were collected from the 1:4 M China Soil Map and a search work from the Second Soil Survey in China. Results indicated that the SOC stocks were 28.8 Pg C and 88.5 Pg C in soils at depths of 0–20 cm and 0–100 cm, corresponding to significant increases of 5.66% and 5.44%, respectively. Regression analysis revealed that the SOC stock accumulated with the increase of areas on 3-D surfaces. These results provide more reasonable estimates and new references about SOC stocks in terrestrial ecosystems of China. The method of estimation on 3-D surfaces has scientific meaning to promote the development of new approaches to estimate accurate SOC stocks. Full article

Background: Atherosclerosis is a fundamental pathological process responded to some serious cardiovascular events. Although the cholesterol-lowering drugs are widely prescribed for atherosclerosis therapy, it is still the leading cause of death in the developed world. Here we measured the effects of compound K in atherosclerosis formation and investigated the probably mechanisms of the anti-antherosclerosis roles of compound K. Methods: We treated the atherosclerotic model animals (apoE^−/− mice on western diet) with compound K and measured the size of atherosclerotic lesions, inflammatory cytokine levels and serum lipid profile. Peritoneal macrophages were collected in vitro for the foam cell and inflammasome experiments. Results: Our results show that treatment with compound K dose-dependently attenuates the formation of atherosclerotic plaques by 55% through activation of reverse cholesterol transport pathway, reduction of systemic inflammatory cytokines and inhibition of local inflammasome activity. Compound K increases the cholesterol efflux of macrophage-derived foam cells, and reduces the inflammasome activity in cholesterol crystal stimulated macrophages. The activation of LXRα may contribute to the athero-protective effects of compound K. Conclusion: These observations provide evidence for an athero-protective effect of compound K via LXRα activation, and support its further evaluation as a potential effective modulator for the prevention and treatment of atherosclerosis. Full article

Changes in vegetation activity are driven by multiple natural and anthropogenic factors, which can be reflected by Normalized Difference Vegetation Index (NDVI) derived from satellites. In this paper, NDVI trends from 1982 to 2012 are first estimated by the Theil–Sen median slope method to explore their spatial and temporal patterns. Then, the impact of climate variables and human activity on the observed NDVI trends is analyzed. Our results show that on average, NDVI increased by 0.46 × 10⁻³ per year from 1982 to 2012 globally with decadal variations. For most regions of the world, a greening (increasing)–browning (decreasing)–greening (G-B-G) trend is observed over the periods 1982–2004, 1995–2004, and 2005–2012, respectively. A positive partial correlation of NDVI and temperature is observed in the first period but it decreases and occasionally becomes negative in the following periods, especially in the Humid Temperate and Dry Domain Regions. This suggests a weakened effect of temperature on vegetation growth. Precipitation, on the other hand, is found to have a positive impact on the NDVI trend. This effect becomes stronger in the third period of 1995–2004, especially in the Dry Domain Region. Anthropogenic effects and human activities, derived here from the Human Footprint Dataset and the associated Human Influence Index (HII), have varied impacts on the magnitude (absolute value) of the NDVI trends across continents. Significant positive effects are found in Asia, Africa, and Europe, suggesting that intensive human activity could accelerate the change in NDVI and vegetation. A more accurate attribution of vegetation change to specific climatic and anthropogenic factors is instrumental to understand vegetation dynamics and requires further research. Full article