Cascade hydropower stations are effective in water resource utilization, regional water allocation, and flood risk management. Under changing climate conditions, water resources would experience complex temporal and spatial changes, which may lead to various issues relating to flood control and water resource management, and challenge the existing optimal scheduling of cascade hydropower stations. It is thus important to conduct a study on cascade hydropower station scheduling under changing climate conditions. In this study, the Jinsha River rainfall–discharge statistical model is developed based on the statistical relationship between meteorological and runoff indicators. Validation results indicate that the developed model is capable of generating satisfactory simulation results and thus can be used for future Jinsha River runoff projection under climate change. Meanwhile, the Providing Regional Climates for Impacts Studies (PRECIS) is run to project future rainfall in the Jinsha River basin under two General Circulation Models (ECHAM5 and HadAM3P), two scenarios (A1B and B2), and four periods (1961–1990, 1991–2020, 2021–2050, and 2051–2099). The regional climate modeling data are analyzed and then fed into the Jinsha hydrological model to analyze the trends of future discharge at Xiangjiaba Hydro Station. Adaptive scheduling strategies for cascade hydropower stations are discussed based on the future inflow trend analysis and current flood scheduling mode. It is suggested that cascade hydropower stations could be operated at flood limited water level (FLWL) during 2021–2099. In addition, the impoundment of cascade hydropower stations should be properly delayed during the post-flood season in response to the possible occurrence of increased and extended inflow in wet seasons. Full article

Background: Folic acid supplementation is effective in reducing the risk of neural tube defects (NTDs). However, the use of folic acid is low among rural women in China. Nutrition education can provide information about folic acid and encourage its use. The primary objective of this study was to test the effectiveness of a village‐based nutrition intervention on folic acid use among rural women. Methods: Sixty villages were randomly selected using multiple‐stage sampling and were divided into control and intervention groups. The intervention included nutritional education at village clinics, written materials, and text messages (SMS). Folic acid use knowledge and behavior was assessed at baseline and after the intervention. Results: Self‐reported compliance with folic acid supplement use increased from 17.0%–29.2% at baseline to 41.7%-59.2% one year post‐intervention. During the same period, the folic acid knowledge score in the intervention group increased from 3.07 to 3.65, significantly higher than the control group (3.11 to 3.35). Multivariate binary logistic regression showed that the women who received folic acid education and SMS intervention were more likely to comply with folic acid supplement recommendations. Conclusions: The results indicated that an integrated village‐based folic acid education intervention may be an effective way of promoting folic acid use for the prevention of NTDs in rural women. Full article

Diabetes mellitus is a chronic metabolic condition that affects carbohydrate, lipid and protein metabolism and may impair numerous organs and functions of the organism. Cardiac dysfunction afflicts many patients who experience the oxidative stress of the heart. Diabetic cardiomyopathy (DCM) is one of the major complications that accounts for more than half of diabetes-related morbidity and mortality cases. Chronic hyperglycemia and hyperlipidemia from diabetes mellitus cause cardiac oxidative stress, endothelial dysfunction, impaired cellular calcium handling, mitochondrial dysfunction, metabolic disturbances, and remodeling of the extracellular matrix, which ultimately lead to DCM. Although many studies have explored the mechanisms leading to DCM, the pathophysiology of DCM has not yet been fully clarified. In fact, as a potential mechanism, the associations between DCM development and mitogen-activated protein kinase (MAPK) activation have been the subjects of tremendous interest. Nonetheless, much remains to be investigated, such as tissue- and cell-specific processes of selection of MAPK activation between pro-apoptotic vs. pro-survival fate, as well as their relation with the pathogenesis of diabetes and associated complications. In general, it turns out that MAPK signaling pathways, such as extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal protein kinase (JNK) and p38 MAP kinase, are demonstrated to be actively involved in myocardial dysfunction, hypertrophy, fibrosis and heart failure. As one of MAPK family members, the activation of ERK1/2 has also been known to be involved in cardiac hypertrophy and dysfunction. However, many recent studies have demonstrated that ERK1/2 signaling activation also plays a crucial role in FGF21 signaling and exerts a protective environment of glucose and lipid metabolism, therefore preventing abnormal healing and cardiac dysfunction. The duration, extent, and subcellular compartment of ERK1/2 activation are vital to differential biological effects of ERK1/2. Moreover, many intracellular events, including mitochondrial signaling and protein kinases, manipulate signaling upstream and downstream of MAPK, to influence myocardial survival or death. In this review, we will summarize the roles of ERK1/2 pathways in DCM development by the evidence from current studies and will present novel opinions on “differential influence of ERK1/2 action in cardiac dysfunction, and protection against myocardial ischemia-reperfusion injury”. Full article

The famous “world’s factory” city, Dongguan, like many other places in China, is a typical beneficiary of China’s Reform and Opening-up Policy. However, rapid urban sprawl and economic growth are at the expense of the destruction of the local environment. Therefore, it is of great importance to establish an ecological security network for sustainable development. InVEST models, effective tools to measure sensitivity and intensity of external threats to quantify habitat value, are used to calculate habitat quality of water and land. By combining structural connectivity and the Least-Cost Path model (LCP model), in which corridors are determined based on the minimum accumulative cost path between each critical point, ecological security patterns were calculated. According to the results, the northwest region of Dongguan, having a large quantity of farmlands and water and therefore many corridors and critical patches, is the most essential area in the overall security of ecological environments, which should be protected first. If developed, it should be dominated by eco-tourism and eco-agriculture. We hope that research on the ecological network, which includes critical patches and corridors formed by greenland and rivers, will lead toward better-informed proposals for local urban planning and regional sustainable development. Full article