In some application domains, using a download cable to update the system on a programmable chip (SoPC) is infeasible, which reduces the maintainability and flexibility of the system. Hence the remote system update (RSU) scheme is being studied. In this scheme, the serial configuration (EPCS) device involves a factory mode configuration image, which acts as the baseline, and an application mode configuration image, which is used for some specific functions. Specifically, a new application mode image is delivered through the controller area network (CAN) with the improved application layer protocol. Besides, the data flow and data check for transmitting a new image are constructed to combine the transmission reliability with efficiency. The boot sequence copying hardware configuration code and software configuration code is analyzed, and the advanced boot loader is carried out to specify boot address of the application mode image manually. Experiments have demonstrated the feasibility of updating and running a new application mode image, as well as rolling back into the factory mode image when no application mode image is available. This scheme applies a single CAN bus, which makes the system easy to construct and suitable for the field distributed control system. Full article

The aim of this study was to determine whether the increased serum cell-free fetal DNA (cffDNA) level of gravidas developed into early-onset preeclampsia (EOPE) subsequently in the early second trimesters is related to prenatal screening markers. Serum was collected from 1011 gravidas. The level of cffDNA and prenatal screening markers were analyzed in 20 cases with EOPE and 20 controls. All fetuses were male. The maternal serum cffDNA level was assessed by amplification of the Y chromosome specific gene. Correlations between the variables were examined. (Logged) cffDNA in EOPE (median, 3.08; interquartile range, 2.93–3.68) was higher than controls (median, 1.79; interquartile range, 1.46–2.53). The increased level of (logged) cffDNA was correlated significantly with the increased human chorionic gonadotropin (HCG) level (r = 0.628, p < 0.001). Significant reciprocal correlations between cffDNA and babies’ birth weight as well as gestation weeks at delivery were noted (r = −0.516, p = 0.001; r = −0.623, p < 0.001, respectively). The sensitivity and specificity of cffDNA to discriminate between the EOPE cases and the controls were 90% and 85%, respectively. CffDNA is a potential marker for EOPE, which had a significant reciprocal correlation with babies’ birth weight and gestation weeks at delivery. Moreover, it may help in indicating the underlying hypoxic condition in the placenta. Full article