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Authors = Andrew L. Schwaderer

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Open AccessReview Genetic Variations in Vesicoureteral Reflux Sequelae
Pathogens 2016, 5(1), 14; doi:10.3390/pathogens5010014
Received: 11 September 2015 / Revised: 20 January 2016 / Accepted: 21 January 2016 / Published: 2 February 2016
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Abstract
Urinary tract infections (UTI) are a common condition in children. Vesicoureteral reflux (VUR) represents a common associated condition with childhood UTI. UTI susceptibility appears to have a genetic component based on family and UTI cohort studies. Targeted analysis of innate immune system genetic
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Urinary tract infections (UTI) are a common condition in children. Vesicoureteral reflux (VUR) represents a common associated condition with childhood UTI. UTI susceptibility appears to have a genetic component based on family and UTI cohort studies. Targeted analysis of innate immune system genetic variations indicate that these variations are important in UTI susceptibility. In this overview, we discuss how current cohorts and genetic strategies can be implemented to discover new susceptibility loci in patients with UTI. Full article
(This article belongs to the Special Issue Molecular Aspects of Urinary Tract Infection)

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