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English correction fees (250 CHF) will be added in certain cases (1050 CHF per paper for those papers that require extensive additional formatting and/or English corrections.). http://www.mdpi.com/1420-3049/15/7/5053/ Unmanaged sudden withdrawal from the excessive consumption of alcohol (ethanol) adversely alters neuronal integrity in vulnerable brain regions such as the cerebellum, hippocampus, or cortex. In addition to well known hyperexcitatory neurotransmissions, ethanol withdrawal (EW) provokes the intense generation of reactive oxygen species (ROS) and the activation of stress-responding protein kinases, which are the focus of this review article. EW also inflicts mitochondrial membranes/membrane potential, perturbs redox balance, and suppresses mitochondrial enzymes, all of which impair a fundamental function of mitochondria. Moreover, EW acts as an age-provoking stressor. The vulnerable age to EW stress is not necessarily the oldest age and varies depending upon the target molecule of EW. A major female sex steroid, 17β-estradiol (E2), interferes with the EW-induced alteration of oxidative signaling pathways and thereby protects neurons, mitochondria, and behaviors. The current review attempts to provide integrated information at the levels of oxidative signaling mechanisms by which EW provokes brain injuries and E2 protects against it. http://www.mdpi.com/1420-3049/15/7/5053/ Fri, 23 Jul 2010 00:00:00 CEST Molecules 2010-07-23 15 7 Article 5053 5065 1420-3049 An Amperometric Immunosensor Based on a Polyelectrolyte/ Gold Magnetic Nanoparticle Supramolecular Assembly—Modified Electrode for the Determination of HIV p24 in Serum 2010-07-23 doi: 10.3390/molecules15075053 Ning Gan Jianguo Hou Futao Hu Lei Zheng Minjun Ni Yuting Cao http://www.mdpi.com/1420-3049/15/5/3709/ The number of synthetic methods enabling the preparation of ammonium-based rotaxanes has increased very rapidly in the past ten years. The challenge in the synthesis of rotaxanes results from the rather weak interactions between the ammonium-containing rod and the crown ether macrocycle in the pseudorotaxane structure that rely mostly on O•H hydrogen bonds. Indeed, no strong base or polar solvent that could break up H-bonding can be used during the formation of rotaxanes because the two components will separate as two distinct entities. Moreover, most of the reactions have to be performed at room temperature to favor the formation of pseudorotaxane in solution. These non-trivial prerequisites have been taken into account to develop efficient reaction conditions for the preparation of rotaxanes and those are described in detail along this review. http://www.mdpi.com/1420-3049/15/5/3709/ Tue, 25 May 2010 00:00:00 CEST Molecules 2010-05-25 15 5 Review 3709 3730 1420-3049 Recent Advances in the Synthesis of Ammonium-Based Rotaxanes 2010-05-25 doi: 10.3390/molecules15053709 Thibeault Morin http://www.mdpi.com/1420-3049/15/5/3478/ This paper provides a brief review of recent progress in the field of metal coordination polymers assembled from azole-containing carboxylic acids and gives a diagrammatic summary of the diversity of topological structures in the resulting infinite metal-organic coordination networks (MOCNs). Azole-containing carboxylic acids are a favorable kind of multifunctional ligand to construct various metal complexes with isolated complexes and one, two and three dimensional structures, whose isolated complexes are not the focus of this review. An insight into the topology patterns of the infinite coordination polymers is provided. Analyzed topologies are compared with documented topologies and catalogued by the nature of nodes and connectivity pattern. New topologies which are not available from current topology databases are described and demonstrated graphically. http://www.mdpi.com/1420-3049/15/5/3478/ Wed, 12 May 2010 00:00:00 CEST Molecules 2010-05-12 15 5 Review 3478 3506 1420-3049 Supramolecular Coordination Assemblies Constructed From Multifunctional Azole-Containing Carboxylic Acids 2010-05-12 doi: 10.3390/molecules15053478 Deng Liu Yu Yao http://www.mdpi.com/1420-3049/15/1/226/ A new D3h symmetric triptycene derivative has been synthesized with the aim of obtaining molecules that are able to assemble into porous structures, and can be used in the development of new ligands. The synthesis involves a Diels-Alder reaction as the key step, followed by an oxidation and the formation of a maleimide ring. Triptycene trimaleimide furnished single crystals which have been analyzed by means of X-ray diffraction. http://www.mdpi.com/1420-3049/15/1/226/ Thu, 07 Jan 2010 00:00:00 CET Molecules 2010-01-07 15 1 Communication 226 232 1420-3049 Synthesis and Structure of D3h-Symmetric Triptycene Trimaleimide 2010-01-07 doi: 10.3390/molecules15010226 Cristiano Zonta Ottorino De Lucchi Anthony Linden Martin Lutz