http://www.mdpi.com/journal/molecules/special_issues/ring-closing/ Dear Colleagues, The synthetic applications based on metathesis processes have recieved a huge attention over the past years. It has been an exciting adventure that will continue in the future based on the improvement in catalyst activity, tolerance and selectivity. New commercial and academic applications can be envisioned and the number of total synthesis of natural products based on these methodologies increases more and more. Ring closing metathesis (RCM) is an atom-economical reaction, compatible with many functional groups and allows the constuction of rings of practically any size including macrocycles. This special issue of Molecules will include new exciting contributions in RCM chemistry. Prof. Dr. Javier Pérez-Castells Guest Editor   Submission All manuscripts should be submitted to molecules@mdpi.com with a copy to the Guest Editor. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.   Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI. Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this Open Access journal is 1400 CHF per accepted paper. http://www.mdpi.com/1420-3049/15/9/6638/ Applications of ring-closing alkene metathesis (RCM) in acyclic α- and β-peptides and closely related systems are reviewed, with a special emphasis on the structural and pharmacological effects of cyclization by RCM. http://www.mdpi.com/1420-3049/15/9/6638/ Tue, 21 Sep 2010 00:00:00 CEST Molecules 2010-09-21 15 9 Review 6638 6677 1420-3049 Structural and Pharmacological Effects of Ring-Closing Metathesis in Peptides 2010-09-21 doi: 10.3390/molecules15096638 Øyvind Jacobsen Jo Klaveness Pål Rongved http://www.mdpi.com/1420-3049/15/8/5756/ The synthesis of a monosilylated Grubbs-Hoveyda ruthenium alkylidene complex is described, as well as the preparation and characterization of the corresponding material by sol-gel cogelification with tetraethoxysilane (TEOS) and the assay of this recyclable supported catalyst in ring-closing diene and enyne metathesis reactions under thermal and microwave conditions. http://www.mdpi.com/1420-3049/15/8/5756/ Mon, 23 Aug 2010 00:00:00 CEST Molecules 2010-08-23 15 8 Article 5756 5767 1420-3049 Organic-Inorganic Hybrid Silica Material Derived from a Monosilylated Grubbs-Hoveyda Ruthenium Carbene as a Recyclable Metathesis Catalyst 2010-08-23 doi: 10.3390/molecules15085756 Guadalupe Borja Roser Pleixats Ramón Alibés Xavier Cattoën Michel Wong Chi Man http://www.mdpi.com/1420-3049/15/7/5045/ We have developed a Pt(COD)Cl2-catalyzed hydrative cyclization of 1,6-diynes leading to the formation of functionalized cyclohexenones in good yields. http://www.mdpi.com/1420-3049/15/7/5045/ Fri, 23 Jul 2010 00:00:00 CEST Molecules 2010-07-23 15 7 Article 5045 5052 1420-3049 Platinum-Catalyzed Hydrative Cyclization of 1,6-Diynes for the Synthesis of 3,5-Substituted Conjugated Cyclohexenones 2010-07-23 doi: 10.3390/molecules15075045 Chen Zhang Jian-Feng Qi Dong-Mei Cui Qian Wang Xiu-Li Wang http://www.mdpi.com/1420-3049/15/6/4242/ Medium sized carbocycles are particularly difficult to synthesize. Ring closing metathesis reactions (RCM) have recently been applied to construct eight-membered carbocycles, but trisubstituted double bonds in the eight-membered rings are more difficult to produce using RCM reactions. In this review, model examples and our own results are cited and the importance of the preparation of suitably designed precursors is discussed. Examples of RCM reactions used in the total synthesis of natural products are also outlined. http://www.mdpi.com/1420-3049/15/6/4242/ Fri, 11 Jun 2010 00:00:00 CEST Molecules 2010-06-11 15 6 Review 4242 4260 1420-3049 Construction of Eight-Membered Carbocycles with Trisubstituted Double Bonds Using the Ring Closing Metathesis Reaction 2010-06-11 doi: 10.3390/molecules15064242 Tori Mizutani