http://www.mdpi.com/journal/marinedrugs/special_issues/marine_natural_products/ Manuscript submission Manuscripts should be prepared according to the Instructions for Authors and submitted by e-mail to marinedrugs@mdpi.com, with copy to Prof. Dr. Jordan K. Zjawiony (jordan@olemiss.edu). The subject title of the message should be "Manuscript for Special Issue on Marine Natural Products as Anti-Cancer Agents". Deadline for article submission: 30 May 2008 (Papers can be continuously submitted processed and if accepted, continuously published) http://www.mdpi.com/1660-3397/5/2/23/ In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies. http://www.mdpi.com/1660-3397/5/2/23/ Mon, 25 Jun 2007 00:00:00 CEST Marine Drugs 2007-06-25 5 2 Article 23 30 1660-3397 Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A 2007-06-25 doi: 10.3390/md502023 Gerhard Bringmann Tobias A. M. Gulder Gerhard Lang Stefanie Schmitt Rüdiger Stöhr Jutta Wiese Kerstin Nagel Johannes F. Imhoff