http://www.mdpi.com/journal/molecules/special_issues/ecsoc-13/ {snippet name="submission_info"} http://www.mdpi.com/1420-3049/15/12/8973/ Mixtures of ibandronate monosodium salt with eleven gluco- and/or galacto-pyranoside derivatives as counterions were designed to prepare co-crystals with improved intestinal absorption. In general, gastrointestinal absorption of bisphosphonates after oral administration is approximately 1%. Co-crystals were generated by means of thermodynamically and/or kinetically controlled crystallization processes. Seventy-seven prepared samples were analyzed by means of FT-NIR, FT-Raman spectrometry and solid state NMR spectroscopy. New entities of ibandronate monosodium salt with phenyl-β-d-galactopyranoside were found and characterized. The absorption of these potential new co-crystals was investigated by means of PAMPA experiments. In the present study the relationships between the chemical structures of the studied compounds required for co-crystal generation are discussed. http://www.mdpi.com/1420-3049/15/12/8973/ Wed, 08 Dec 2010 00:00:00 CET Molecules 2010-12-08 15 12 Article 8973 8987 1420-3049 Preparation and Properties of New Co-Crystals of Ibandronate with Gluco- or Galactopyranoside Derivatives 2010-12-08 doi: 10.3390/molecules15128973 Zbynek Oktabec Jiri Kos Zuzana Mandelova Lenka Havelkova Tomas Pekarek Anna Rezacova Lukas Placek Marcela Tkadlecova Jaroslav Havlicek Jiri Dohnal Josef Jampílek http://www.mdpi.com/1420-3049/15/6/4283/ A library of 19 novel 4-(4-phenylpiperazine-1-yl)benzamidines has been synthesized and evaluated in vitro against Pneumocystis carinii. Among these compounds, N-ethyl- and N-hexyl-4-(4-phenylpiperazine-1-yl)benzamidines emerged as the most promising compounds, with inhibition percentages at 10.0 µg/mL of 87% and 96%, respectively. Those compounds remained active at 0.1 µg/mL. http://www.mdpi.com/1420-3049/15/6/4283/ Fri, 11 Jun 2010 00:00:00 CEST Molecules 2010-06-11 15 6 Article 4283 4293 1420-3049 Bisbenzamidines as Antifungal Agents. Are Both Amidine Functions Required to Observe an Anti-Pneumocystis carinii Activity? 2010-06-11 doi: 10.3390/molecules15064283 Laurent Stanicki Huang Dei-Cas Pottier Aliouat Vanden Eynde http://www.mdpi.com/1420-3049/15/3/1213/ The association constants Kb of three hosts I–III designed to have both enhanced hydrogen bonding donor strength and conformational preorganization with biotin analogues 1–5 are reported. 1H-NMR titrations under two different concentration conditions have been employed to determine the association constants Kb. A statistical analysis using a presence absence matrix has been applied to calculate the different contributions. Hydrogen bond interactions make naphthyridine derivatives II and III potent binders and effective receptors for (+)-biotin methyl ester (1), due to the complex stabilization by additional hydrogen bonds. http://www.mdpi.com/1420-3049/15/3/1213/ Wed, 03 Mar 2010 00:00:00 CET Molecules 2010-03-03 15 3 Article 1213 1222 1420-3049 Molecular Recognition Studies on Naphthyridine Derivatives 2010-03-03 doi: 10.3390/molecules15031213 José Carlos Iglesias-Sánchez Dolores Santa María Rosa M. Claramunt José Elguero