http://www.mdpi.com/journal/molecules/special_issues/ecsoc-11/ This will be the 11th meeting of ECSOC since 1997. All accepted papers will be posted as websites during 1–30 November 2007. Discussions in the form of e-mail exchanges or bulletin boards will be possible. The ECSOC-11 Proceedings will be published later online and as a CD-ROM edition. Posters presented at ECSOC-11 may be considered as preliminary communications of research results (or review papers) and may be published in another form later in any standard journal. At the authors discretion, contributions will be removed from the web-site after the end of the conference and not included in the online and CD-ROM ECSOC-11 Proceedings as a book (ISBN: 3-906980-19-7, to be published at the end of conference). Authors are invited to publish their papers subsequently in Molecules (http://www.mdpi.org/molecules) We accept only those papers presented at ECSOC-11 for consideration and publication in this special issue. An invitation was sent to the mailing list of ECSOC-11 on 3 December 2007. It is fine to publish the same paper as presented at ECSOC-11. It is a normal practice to publish papers in a journal after presenting at a conference. However, if possible, please add as much as possible more data and experimental details. We would like to publish long papers, as a policy which can be found in the Editorial of Molecules at http://www.mdpi.org/molecules/edito96.htm. All papers will be peer-reviewed. Manuscripts should be prepared according to the Instructions for Authors and submitted by e-mail to molecules@mdpi.org, with copy to the Guest Editor Dr. Julio A. Seijas Vázquez, E-mail: qoseijas@LUGO.USC.ES and the Editor-in-Chief, Dr. Derek J. McPhee, E-mail: mcphee@mdpi.org. The subject title of the message should be "Special Issue ECSOC-11", mentioning the paper number given at ECSOC-11. Deadline for article submission: 28 February 2008 (Papers can be continuously submitted, processed and if accepted, continuously published). http://www.mdpi.com/1420-3049/13/1/157/ Unsubstituted cyclic imides were synthesized from a series of cyclic anhydrides,hydroxylamine hydrochloride (NH2OH·HCl), and 4-N,N-dimethylamino-pyridine (DMAP,base catalyst) under microwave irradiation in monomode and multimode microwaves. Thisnovel microwave synthesis produced high yields of the unsubstituted cyclic imides forboth the monomode (61 - 81%) and multimode (84 - 97%) microwaves. http://www.mdpi.com/1420-3049/13/1/157/ Fri, 25 Jan 2008 00:00:00 CET Molecules 2008-01-25 13 1 Article 157 169 1420-3049 The Synthesis of Unsubstituted Cyclic Imides Using Hydroxylamine under Microwave Irradiation 2008-01-25 doi: 10.3390/molecules13010157 Ellis Benjamin Yousef Hijji http://www.mdpi.com/1420-3049/13/1/86/ The unexpected substitution of fluorine atoms and phenoxy groups attached toquinoxaline or benzofuroxan rings is described. The synthesis of 2-benzyl- and 2-phenoxy-3-methylquinoxaline 1,4-di-N-oxide derivatives was based on the classical Beirut reaction.The tendency of fluorine atoms linked to quinoxaline or benzofuroxan rings to be replacedby a methoxy group when dissolved in an ammonia saturated solution of methanol wasclearly demonstrated. In addition, 2-phenoxyquinoxaline 1,4-di-N-oxide derivativesbecame 2-aminoquinoxaline 1,4-di-N-oxide derivatives in the presence of gaseousammonia. http://www.mdpi.com/1420-3049/13/1/86/ Fri, 18 Jan 2008 00:00:00 CET Molecules 2008-01-18 13 1 Article 86 95 1420-3049 Substitutions of Fluorine Atoms and Phenoxy Groups in the Synthesis of Quinoxaline 1,4-di-N-oxide Derivatives 2008-01-18 doi: 10.3390/molecules13010086 Esther Vicente Raquel Villar Asunción Burguete Beatriz Solano Saioa Ancizu Silvia Pérez-Silanes Ignacio Aldana Antonio Monge http://www.mdpi.com/1420-3049/13/1/78/ The unexpected tendency of amines and functionalized hydrazines to reduceethyl 3-phenylquinoxaline-2-carboxylate 1,4-di-N-oxide (1) to afford a quinoxaline 1c andmono-oxide quinoxalines 1a and 1b is described. The experimental conditions werestandardized to the use of two equivalents of amine in ethanol under reflux for two hours,with the aim of studying the distinct reductive profiles of the amines and thechemoselectivity of the process. With the exception of hydrazine hydrate, which reducedcompound 1 to a 3-phenyl-2-quinoxalinecarbohydrazide derivative, the amines only actedas reducing agents. http://www.mdpi.com/1420-3049/13/1/78/ Thu, 17 Jan 2008 00:00:00 CET Molecules 2008-01-17 13 1 Article 78 85 1420-3049 Unexpected Reduction of Ethyl 3-Phenylquinoxaline-2- carboxylate 1,4-Di-N-oxide Derivatives by Amines 2008-01-17 doi: 10.3390/molecules13010078 Lidia M. Lima Esther Vicente Beatriz Solano Silvia Pérez-Silanes Ignacio Aldana Antonio Monge http://www.mdpi.com/1420-3049/13/1/69/ The aim of this study was to identify new compounds active againstPlasmodium falciparum based on our previous research carried out on 3-phenylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives. Twelve compounds weresynthesized and evaluated for antimalarial activity. Eight of them showed an IC50 less than 1 μMagainst the 3D7 strain. Derivative 1 demonstrated high potency (IC50= 0.63 μM) and goodselectivity (SI=10.35), thereby becoming a new lead-compound. http://www.mdpi.com/1420-3049/13/1/69/ Thu, 17 Jan 2008 00:00:00 CET Molecules 2008-01-17 13 1 Article 69 77 1420-3049 Synthesis and Antiplasmodial Activity of 3-Furyl and 3-Thienylquinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives 2008-01-17 doi: 10.3390/molecules13010069 Esther Vicente Sarah Charnaud Emily Bongard Raquel Villar Asunción Burguete Beatriz Solano Saioa Ancizu Silvia Pérez-Silanes Ignacio Aldana Livia Vivas Antonio Monge