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English correction fees (250 CHF) will be added in certain cases (1050 CHF per paper for those papers that require extensive additional formatting and/or English corrections.). http://www.mdpi.com/1420-3049/14/8/2850/ Onenewalkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1),together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl)lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC50 value of 3.9 μg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS. http://www.mdpi.com/1420-3049/14/8/2850/ Fri, 31 Jul 2009 00:00:00 CEST Molecules 2009-07-31 14 8 Article 2850 2856 1420-3049 (+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees 2009-07-31 doi: 10.3390/molecules14082850 Tiah Rachmatiah Mat Ropi Mukhtar Mohd Azlan Nafiah Muhammad Hanafi Soleh Kosela Hiroshi Morita Marc Litaudon Khalijah Awang Hanita Omar A. Hamid A. Hadi http://www.mdpi.com/1420-3049/14/3/1227/ The stem bark of Phoebe grandis afforded one new oxoproaporphine; (–)-grandine A (1), along with six known isoquinoline alkaloids: (–)-8,9-dihydrolinearisine (2), boldine, norboldine, lauformine, scortechiniine A and scortechiniine B. In addition to that of the new compound, complete 1H- and 13C-NMR data of the tetrahydroproaporphine (–)-8,9-dihydrolinearisine (2) is also reported. The alkaloids’ structures were elucidated primarily by means of high field 1D- and 2D-NMR and HRMS spectral data. http://www.mdpi.com/1420-3049/14/3/1227/ Mon, 23 Mar 2009 00:00:00 CET Molecules 2009-03-23 14 3 Article 1227 1233 1420-3049 Grandine A, a New Proaporphine Alkaloid from the Bark of Phoebe grandis 2009-03-23 doi: 10.3390/molecules14031227 Mat Ropi Mukhtar Ahmad Nazif Aziz Noel F. Thomas A. Hamid A. Hadi Marc Litaudon Khalijah Awang http://www.mdpi.com/1420-3049/14/3/917/ Treatment of 1-(2-bromoarylmethyl)-3,4-dihydroisoquinolines with oxalyl chloride and triethylamine gave 1-(2-bromophenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2,3-dione derivatives, for example, 1-(2-bromophenyl)-5,6-dihydro-8,9-dimethoxypyrrolo[2,1-a]isoquinoline-2,3-dione. Radical cyclisation of these derivatives with tributyltin hydride and 1,1-azobis(cyclohexanecarbonitrile) afforded telisatin A, telisatin B and lettowianthine. http://www.mdpi.com/1420-3049/14/3/917/ Thu, 26 Feb 2009 00:00:00 CET Molecules 2009-02-26 14 3 Article 917 924 1420-3049 Total Syntheses of Telisatin A, Telisatin B and Lettowianthine 2009-02-26 doi: 10.3390/molecules14030917 Surachai Nimgirawath Phansuang Udomputtimekakul http://www.mdpi.com/1420-3049/14/1/89/ The structure previously assigned to the phenolic noraporphine alkaloid, (-)-norannuradhapurine has been confirmed by a total synthesis of the racemic alkaloid in which the key step involved the formation of the C ring by a radical-initiated cyclization. although inactive against Staphylococcus aureus ATCC25932, Escherichia coli ATCC10536 and Candida albicans ATCC90028, (±)-norannuradhapurine inhibits the production of NO, PGE2, TNF-a, IL-1b and IL-6 and the expression of iNOS and COX-2 in RAW 264.7 macrophages stimulated with LPS in vitro. http://www.mdpi.com/1420-3049/14/1/89/ Mon, 29 Dec 2008 00:00:00 CET Molecules 2008-12-29 14 1 Article 89 101 1420-3049 Total Synthesis and the Biological Activities of (±)-Norannuradhapurine 2008-12-29 doi: 10.3390/molecules14010089 Surachai Nimgirawath Rujee Lorpitthaya Asawin Wanbanjob Thongchai Taechowisan Yue-Mao Shen http://www.mdpi.com/1420-3049/13/12/2935/ The structures previously assigned to (+)-laurelliptinhexadecan-1-one (1a) and (+)-laurelliptinoctadecan-1-one (1b) from Cocculus orbiculatus (L.) DC. (Menispermaceae) have been confirmed by total synthesis of the racemic alkaloids. The key step of the synthesis involved formation of ring C of the aporphines by a radical-intiated cyclisation. Both (±)-laurelliptinhexadecan-1-one (1a) and (±)-laurelliptinoctadecan-1-one (1b) were inactive against Staphylococcus aureus ATCC25932, Escherichia coli ATCC10536 and Candida albicans ATCC90028. http://www.mdpi.com/1420-3049/13/12/2935/ Fri, 28 Nov 2008 00:00:00 CET Molecules 2008-11-28 13 12 Article 2935 2947 1420-3049 Total Synthesis and Antimicrobial Activity of (±)-Laurelliptinhexadecan-1-one and (±)-Laurelliptinoctadecan-1-one 2008-11-28 doi: 10.3390/molecules13122935 Surachai Nimgirawath Phansuang Udomputtimekakul Samathi Pongphuttichai Asawin Wanbanjob Thongchai Taechowisan