http://www.mdpi.com/journal/molecules/special_issues/acetogenins/ Submission All papers should be submitted to molecules@mdpi.com with copy to the guest editor. To be published continuously until the deadline and papers will be listed together at the special websites. Submitted papers should not have been previously published nor be currently under consideration for publication elsewhere. All papers are refereed through a peer review process. A guide for authors, sample copies and other relevant information for submitting papers are available on the Instructions for Authors page. Molecules is an international peer-reviewed monthly journal published by MDPI. Please visit the Instructions for Authors page before submitting a paper. Open Access publication fees are 800 CHF per paper. English correction fees (250 CHF) will be added in certain cases (1050 CHF per paper for those papers that require extensive additional formatting and/or English corrections). http://www.mdpi.com/1420-3049/15/1/460/ The synthesis of the subgroups of acetogenins containing non-adjacent bis-THF and non-adjacent THF-THP core units is reviewed. Specifically, total syntheses of gigantecin, 4-deoxygigantecin, cis-sylvaticin, squamostatin-C, squamostatin-D, sylvaticin and mucocin are discussed. http://www.mdpi.com/1420-3049/15/1/460/ Thu, 21 Jan 2010 00:00:00 CET Molecules 2010-01-21 15 1 Review 460 501 1420-3049 Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes 2010-01-21 doi: 10.3390/molecules15010460 Ian B. Spurr Richard C. D. Brown http://www.mdpi.com/1420-3049/14/12/5235/ Annonaceous acetogenins are proposed as environmental neurotoxicants consumed through medicinal and alimentary habits and responsible for atypical parkinsonian syndromes observed in tropical areas. Potential sources of exposure still have to be determined, as, to date, only a few batches of products for human consumption were searched for these compounds. To assess the presence of acetogenins, we propose a fast, sensitive and accurate method of screening, using MALDI-TOF MS, with minimal sample preparation. Development of the technique is discussed. Its application to leaves of herbal tea, pulp and bottled nectar of Annona muricata is presented. http://www.mdpi.com/1420-3049/14/12/5235/ Tue, 15 Dec 2009 00:00:00 CET Molecules 2009-12-15 14 12 Communication 5235 5246 1420-3049 MALDI-TOF MS Profiling of Annonaceous Acetogenins in Annona muricata Products for Human Consumption 2009-12-15 doi: 10.3390/molecules14125235 Pierre Champy Vincent Guérineau Olivier Laprévote http://www.mdpi.com/1420-3049/14/11/4387/ A methylene chloride extract of the pulp of Annona muricata L. was fractionated in search for scarcely functionalized Annonaceous acetogenins (type E). Previously known C-35 and C-37 mono-epoxy unsaturated compounds, epomuricenins-A and -B (1+2) and epomusenins-A and -B (3+4), were obtained. Two new mono-epoxy saturated C-35 representatives, epomurinins-A and -B (5+6) were also isolated. http://www.mdpi.com/1420-3049/14/11/4387/ Mon, 02 Nov 2009 00:00:00 CET Molecules 2009-11-02 14 11 Communication 4387 4395 1420-3049 Apolar Annonaceous Acetogenins from the Fruit Pulp of Annona muricata 2009-11-02 doi: 10.3390/molecules14114387 Alice Melot Djibril Fall Christophe Gleye Pierre Champy http://www.mdpi.com/1420-3049/14/9/3621/ Most Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32/34 fatty acid, and the terminal carboxylic acid is combined with a 2-propanol unit to form an α,β-unsaturated γ-lactone. While many studies have addressed the properties and synthesis of natural acetogenins due to their attractive biological activities and unique structural features, a number of analogues have also been described. This review covers the design, synthesis, and biological evaluation of acetogenin analogues. http://www.mdpi.com/1420-3049/14/9/3621/ Thu, 17 Sep 2009 00:00:00 CEST Molecules 2009-09-17 14 9 Review 3621 3661 1420-3049 Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues 2009-09-17 doi: 10.3390/molecules14093621 Naoto Kojima Tetsuaki Tanaka