Potential Health Risks of Chemicals in Car Colorant Products
Abstract
:1. Introduction
2. Methods
2.1. Sample Collection and Target Chemical Analysis
2.2. Toxicological Information
2.3. Exposure and Risk Assessment
2.3.1. Tier 1 Assessment
Cinh = Ca·abs·t·n/24
2.3.2. Tier 2 Assessment
Cinh = Ca·abs·t·n/24
3. Results
3.1. The Concentration of Target Chemicals in Car Colorant Products
3.2. Toxicological Information
3.3. Exposure Assessment and Risk Characterization
3.3.1. Tier 1 Assessment
3.3.2. Tier 2 Assessment
4. Discussion
5. Conclusions
Author Contributions
Acknowledgments
Conflicts of Interest
References
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Chemicals | Pre-Treatment Method | Analytical Method * | Limit of Quantitation (% w/w) |
---|---|---|---|
Methyl ethyl ketone, Ethyl acetate, Isobutanol, Heptane, Methyl isobutyl ketone, Toluene, Butyl acetate/N-butyl acetate, Ethylbenzene, Xylene, Propylene glycol methyl ether acetate, 2-Butoxyethanol, Cyclohexanone, 2-Butoxyethanol acetate | Solvent extraction | GC/MS | 0.001 |
Acetone, Hexane | Solvent extraction | GC/MS | 0.005 |
Exposure Factors | Percentiles | |
---|---|---|
75th | 95th | |
Frequency of use (events/6 months) | 2.00 a | 3.00 a |
Duration of use (min/use) | 20.00 a | 50.00 a |
Amount of use per application (g/use) | 13.60 a | 27.21 a |
Chemical | Detection Rate (%) | Concentration Range (%) |
---|---|---|
Acetone | 61.5 | 0.011 (0.006, 3.088) |
Hexane | 38.5 | 0.486 (0.024, 0.932) |
Methyl ethyl ketone | 61.5 | 1.373 (0.031, 4.102) |
Ethyl acetate | 38.5 | 0.833 (0.002, 4.991) |
Isobutanol | 46.2 | 0.129 (0.022, 1.207) |
Heptane | 53.8 | 0.161 (0.003, 2.466) |
Methyl isobutyl ketone | 61.5 | 0.053 (0.002, 2.452) |
Toluene | 100.0 | 10.804 (0.055, 52.524) |
Butyl acetate; N-butyl acetate | 69.2 | 17.676 (0.017, 27.457) |
Ethylbenzene | 100.0 | 2.722 (1.090, 24.381) |
Xylene | 100.0 | 4.880 (0.853, 15.492) |
Propylene glycol methyl ether acetate | 62.9 | 1.868 (0.205, 11.410) |
2-Butoxyethanol | 38.5 | 2.352 (1.391, 3.597) |
Cyclohexanone | 23.1 | 0.015 (0.002, 0.726) |
2-Butoxyethanol acetate | 23.1 | 0.012 (0.004, 0.983) |
Chemical | Toxicity Value (NOAEC, NOEC, LOAEC; mg/m3) | End Point | Adjustment Factors (Exposure Time) | Assessment Factors (Exposure Duration) | Reference Toxicological Value (mg/m3) |
---|---|---|---|---|---|
Acetone c | LOAEC = 2952 | Neurological effects | - | LOAEC to NOAEC: 3 | 984.7 |
Hexane b | LOAEC = 10,574 | Nasal lesions | 0.50 | Sub-chronic to chronic: 2 LOAEC to NOAEC: 3 | 881.2 |
Methyl ethyl ketone a | - | Developmental toxicity (skeletal variations) | - | - | 5.0 |
Ethyl acetate b | NOAEC = 1280 | Respiratory irritant effects | 0.18 | Sub-chronic to chronic: 2 | 114.3 |
Isobutanol b | NOAEC = 7500 | No effects observed | 0.18 | Sub-chronic to chronic: 2 | 669.6 |
Heptane b | NOAEC = 12,470 | Body weight changes | 0.50 | Sub-chronic to chronic: 2 | 3117.5 |
Methyl isobutyl ketone a | - | Reduced fetal body weight, skeletal variations, and increased fetal death | - | - | 3.0 |
Toluene a | - | Neurological effects | - | - | 5.0 |
Butyl acetate; N-butyl acetate b | NOAEC = 2400 | Organ-specific toxicity | 0.18 | Sub-chronic to chronic:2 | 214.3 |
Ethylbenzene a | - | Developmental toxicity | - | - | 1.0 |
Xylene a | - | Impaired motor coordination | - | - | 0.1 |
Propylene glycol methyl ether acetate b | NOEC = 1621 | Increase in tumor incidence | 0.18 | Chronic to chronic: 1 | 289.6 |
2-Butoxyethanol a | - | Hemosiderin deposition in the liver | - | - | 1.6 |
Cyclohexanone | N/A | N/A | N/A | N/A | N/A |
2-Butoxyethanol acetate | N/A | N/A | N/A | N/A | N/A |
Chemical | Target MOE/HQ | |
---|---|---|
Tier 1 Assessment | Tier 2 Assessment | |
Acetone | 100 Intra-species: 10 Screening factor 10 | 10 Intra-species: 10 |
Hexane | 250 Intra-species: 10 Inter-species: 2.5, Screening factor 10 | 250 Intra-species: 10 Inter-species: 2.5 |
Methyl ethyl ketone | 0.1 * | 1 * |
Ethyl acetate | 250 Intra-species: 10 Inter-species: 2.5, Screening factor 10 | 25 Intra-species: 10 Inter-species: 2.5 |
Isobutanol | 250 Intra-species: 10 Inter-species: 2.5, Screening factor 10 | 25 Intra-species: 10 Inter-species: 2.5 |
Heptane | 250 Intra-species: 10 Inter-species: 2.5, Screening factor 10 | 25 Intra-species: 10 Inter-species: 2.5 |
Methyl isobutyl ketone | 0.1 * | 1 * |
Toluene | 0.1 * | 1 * |
Butyl acetate; N-butyl acetate | 250 Intra-species: 10 Inter-species: 2.5, Screening factor 10 | 25 Intra-species: 10 Inter-species: 2.5 |
Ethylbenzene | 0.1 * | 1 * |
Xylene | 0.1 * | 1 * |
Propylene glycol methyl ether acetate | 250 Intra-species: 10 Inter-species: 2.5, Screening factor 10 | 25 Intra-species: 10 Inter-species: 2.5 |
2-Butoxyethanol | 0.1 * | 1 * |
Cyclohexanone | N/A | N/A |
2-Butoxyethanol acetate | N/A | N/A |
Chemical | Exposure Concentration (mg/m3) | MOE or HQ a | Health Risk (O = yes, X = no) |
---|---|---|---|
Acetone | 0.05 | 18,830,375 * | X |
Hexane | 0.02 | 55,864,263 * | X |
Methyl ethyl ketone | 0.07 | 0.01 ** | X |
Ethyl acetate | 0.08 | 1,352,490 * | X |
Isobutanol | 0.02 | 32,759,583 * | X |
Heptane | 0.04 | 74,658,040 * | X |
Methyl isobutyl ketone | 0.07 | 0.01 ** | X |
Toluene | 0.89 | 0.2 ** | O |
Butyl acetate; N-butyl acetate | 0.46 | 460,935 * | X |
Ethylbenzene | 0.41 | 0.4 ** | O |
Xylene | 0.26 | 2.6 ** | O |
Propylene glycol methyl ether acetate | 0.19 | 1,498,850 * | X |
2-Butoxyethanol | 0.44 | 0.3 ** | O |
Cyclohexanone | N/A | N/A | N/A |
2-Butoxyethanol acetate | N/A | N/A | N/A |
Chemical | Exposure Concentration (mg/m3) | HQ a | Health Risk (O = yes, X = no) |
---|---|---|---|
Toluene | 0.13 | 0.03 | X |
Ethylbenzene | 0.06 | 0.06 | X |
Xylene | 0.04 | 0.38 | X |
2-Butoxyethanol | 0.01 | 0.01 | X |
Chemical | International Indoor Guide Values * | Current Study | |
---|---|---|---|
II | I | ||
Toluene | 3.0 mg/m3 | 0.3 mg/m3 | 0.13 mg/m3 |
Ethylbenzene | 2.0 mg/m3 | 0.2 mg/m3 | 0.06 mg/m3 |
Xylene | 0.8 mg/m3 | 0.1 mg/m3 | 0.04 mg/m3 |
2-Butoxyethanol | 1.0 mg/m3 | 0.1 mg/m3 | 0.01 mg/m3 |
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Lee, D.; Kim, J.-h.; Hwang, M.; Lim, H.; Seok, K. Potential Health Risks of Chemicals in Car Colorant Products. Int. J. Environ. Res. Public Health 2019, 16, 913. https://doi.org/10.3390/ijerph16060913
Lee D, Kim J-h, Hwang M, Lim H, Seok K. Potential Health Risks of Chemicals in Car Colorant Products. International Journal of Environmental Research and Public Health. 2019; 16(6):913. https://doi.org/10.3390/ijerph16060913
Chicago/Turabian StyleLee, Daeyeop, Joo-hyon Kim, Moonyoung Hwang, Hyunwoo Lim, and Kwangseol Seok. 2019. "Potential Health Risks of Chemicals in Car Colorant Products" International Journal of Environmental Research and Public Health 16, no. 6: 913. https://doi.org/10.3390/ijerph16060913