Special Issue "Retroviral Enzymes"

Guest Editor
Dr. Luis Menéndez-Arias
Centro de Biología Molecular "Severo Ochoa" [Consejo Superior de Investigaciones Científicas (CSIC) & Universidad Autónoma de Madrid], c/ Nicolás Cabrera 1, Campus de Cantoblanco, 28049 Madrid, Spain
Website: http://www2.cbm.uam.es/mkfactory.esdomain/webs/CBMSO/plt_LineasInvestigacion.aspx?IdObjeto=22
E-Mail:
Phone: +34 91 196 4494
Interests: HIV; reverse transcription; drug resistance; genetic variation; proteolytic processing; HIV protease

Dear Colleagues,

The retroviral RNA genome encodes for three enzymes essential for virus replication: (i) the viral protease (PR), that converts the immature virion into a mature virus through the cleavage of precursor polypeptides; (ii) the reverse transcriptase (RT), responsible for the conversion of the single-stranded genomic RNA into double-stranded proviral DNA; and (iii) the integrase (IN) that inserts the proviral DNA into the host cell genome. All of them are important targets for therapeutic intervention. Knowledge on their structure and mechanism of action should help us to design better drugs against AIDS and other diseases caused by retroviruses.

Dr. Luis Menéndez-Arias
Guest Editor

Submission Information

All papers should be submitted to viruses@mdpi.com. To be published continuously until the deadline and papers will be listed together at the special issue website.

Submitted papers should not have been published nor be under consideration for publication elsewhere. All papers are refereed through a peer-review process. A guide for authors is available on the Instructions for Authors page. Viruses is a new international, peer-reviewed, quarterly open access journal published by MDPI.

Article Processing Charges (APC) for publication in this Open Access journal are waived for well-prepared manuscripts submitted by 30 June 2010. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.

• Aspartyl-proteases
• Reverse transcription
• Integration
• Virus maturation
• Antiretroviral drugs
• Drug targets
• Viral mutation and variability