Special Issue "Recent Research on Papillomaviruses"
Deadline for manuscript submissions: closed (30 April 2013)
Dr. Ligia A. Pinto
HPV Immunology Laboratory, National Cancer Institute-Frederick/Science Applications International Corporation-Frederick, Inc., Building 469, Room 111, Frederick, MD 21702, USA
Phone: +301 846 1766
Fax: +301 846 6954
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed Open Access monthly journal published by MDPI.
- human papillomaviruses
- animal papillomavirus
- viral infection
- papillomavirus epidemiology
- papillomavirus immunology/virology
- cervical cancer
- head and neck cancer
- clinical trials
- novel methods
- animal models
Review: Modulation of Apoptotic Pathways by Human Papillomaviruses (HPV): Mechanisms and Implications for Therapy
Viruses 2012, 4(12), 3831-3850; doi:10.3390/v4123831
Received: 16 November 2012; in revised form: 12 December 2012 / Accepted: 14 December 2012 / Published: 18 December 2012| Download PDF Full-text (486 KB) | Download XML Full-text
Review: The Role of Human Papillomavirus in Human Immunodeficiency Virus Acquisition in Men who Have Sex with Men: A Review of the Literature
Viruses 2012, 4(12), 3851-3858; doi:10.3390/v4123851
Received: 22 November 2012; in revised form: 14 December 2012 / Accepted: 17 December 2012 / Published: 18 December 2012| Download PDF Full-text (204 KB) | Download XML Full-text
Viruses 2013, 5(2), 708-731; doi:10.3390/v5020708
Received: 7 January 2013; in revised form: 22 January 2013 / Accepted: 5 February 2013 / Published: 12 February 2013| Download PDF Full-text (604 KB)
Type of Paper: Article
Title: Detection of Human Papilloma Virus and Amplification of Early Genes for Genotypes Identification in Venezuelan Women
Authors: Elvia Michelli 1,2, Luis Téllez1*, José-Andrés Mendoza1, María-Eugenia Noguera3, Melisse Milano4, Reauben Vera1 and Diana Callejas5
Affiliations: 1 Universidad de Los Andes, Laboratorio de Microbiología y Salud Pública del Estado Mérida, Av. Las Américas, Ambulatorio Venezuela, Unidad de Larga Estancia, Estado Mérida, República Bolivariana de Venezuela, CP 5101; E-Mails: email@example.com (E.M.); firstname.lastname@example.org (L.T.); email@example.com (J.-A.M.); firstname.lastname@example.org (R.V.); 2 Universidad de Oriente, Escuela de Ciencias, Calle Bolívar, Escuela de Enfermería, Departamento de Bioanálisis, Cumaná, Estado Sucre, República Bolivariana de Venezuela, CP 6101; 3 Universidad de Los Andes, Departamento de Obstetricia y Ginecología, Instituto Autónomo Hospital Universitario de Los Andes, Av. 16 de Septiembre, Campo de Oro, Estado Mérida, República Bolivariana de Venezuela, CP 5101; E-Mail: email@example.com (M.-E.N.); 4 Universidad de Los Andes, Facultad de Medicina, Departamento de Anatomía Patológica, Av. Don tulio Febres Cordero, Edificio Sede Sur, Nivel Sótano, Estado Mérida, República Bolivariana de Venezuela; E-Mail: firstname.lastname@example.org (M.M.); 5 Universidad del Zulia, Facultad de Medicina, Laboratorio Regional de Referencia Virológica, Instituto de Investigaciones Clínicas Dr. Américo Negrette, Av. 18 con calle 69, Sector Paraíso, Maracaibo, República Bolivariana de Venezuela; E-Mails: email@example.com (D.C.); * Author to whom correspondence should be addressed; E-Mail: firstname.lastname@example.org (L.T.); Tel.: +58-0274-2714943; Fax: +58-0274-240-3151.
Abstract: Genotyping of Human Papilloma Virus (HPV) by molecular methods may enhance assessment information for screening and following of cervical infection. Cervical samples were obtained from 250 women, simultaneously colposcopy and cytological testing was development. HPV detection assays were performed using Hybrid-Capture 2 and by two PCR assays for L1 and E6/E7 regions. A Nested-PCR-Multiplex assay was used for HPV genotyping. HPV were detected in 27.2%, for those samples, 94.12% were positive for at least one genotype, and high-risk HPVs were identified in 98.44%. HPV18 infection was 79.36%, and HPV16 was 38.09%, whether as individuals or as combined infections. About to the age groups, those infections were more frequent in women under 35 years old (64.7%). Pap-smear examination showed that 12 cervical samples had changes suggesting HPV infection (17.64%), wherever colposcopy evaluation was suggestive of HPV infection in 31 DNA-HPV positive samples (45.6%). There was a high frequency of high-risk HPV genotypes, particularly HPV18, alone or in multiple-type infection. Colposcopy findings showed to be the higher predicted value for diagnosis of HPV infection. Results reflect that over 50% of HPV-positive patients had a colposcopy and/or normal cytology within, highlighting the importance of including routine HPV testing along with genotype identification.
Keywords: HPV; genotypes; cervical cancer
Type of Paper: Article
Title: The Cytology and DNA Detection by the PapilloCheck® test in the Diagnosis of Human Papillomavirus Infection.
Authors: Liliana Vieira 1, Adelaide Almeida 2 ,*
Affiliations: 1 Departamento de Biologia, Universidade de Aveiro, 3810-193 Aveiro, Portugal; E-mail: email@example.com; 2 Departamento de Biologia and CESAM, Universidade de Aveiro, 3810-193 Aveiro, Portugal
* Author to whom correspondence should be addressed; E-Mail: firstname.lastname@example.org; Phone: +351 234 370 784
Abstract: The aim of this study was to make a comparison between the results obtained by cytologies and by the detection and genotyping of HPV DNA in the screening of cervical cancer. In this study there were used 994 samples from human females. These were obtained from liquid-based preparations. The samples were analyzed by cytological technique and by the detection of HPV DNAusing the PapilloCheck ® Test. The HPV was detected in 28% of the samples. Most of the cytology lesions appeared in HPV positive samples and, within these, the most serious injuries occurred mostly in samples with multiple HPV infections. The results indicate that, in general, there is a correlation between the detection of HPV DNA and cytology. However, there were some cases that emphasize the limitations of both diagnosis methods (27% cases with viral HPV DNA positive and normal cytologies and about 2% of cytological lesions detected in samples HPV negatives). It is possible to conclude that none of the two techniques is enough by itself and should be applied together in order to increase the accuracy of cervical cancer screening.
Keywords: Human Papillomavirus, cervical cancer, cytology, PapilloCheck®Test Kit
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Review
Title: Role of IL-10 and TGF- ß1 in Uternine Cervix Immunosuppression in HPV Cervical Lesions and Cervical Cancer
Authors: Kirvis Torres-Poveda, Margarita Bahena-Román, Claudia Madrid-González, Víctor H. Bermúdez-Morales, Oscar Peralta-Zaragoza, and Vicente Madrid-Marina
Affiliation: Division of Chronic Infections and Cancer, Research Center for Infectious Diseases, National Institute of Public Health. Cuernavaca, Mexico.
Corresponding Author: Dr. Madrid-Marina: Instituto Nacional de Salud Pública. Av. Universidad 655, Col. Santa María Ahuacatitlán, Cuernavaca, Morelos. C.P. 62100. Mexico. Tel: +52-17329-3056. E-mail: email@example.com.
Abstract: Clinical and molecular investigations have identified immunological impairment in CC patients. HPV has several mechanisms for avoiding the immune system, it down-regulates the expression of interferon and upregulates IL-10 and TGF-ß1 that produce a local immunosuppressive environment, which altered tumor surface antigens, resulting in the formation of an immunosuppressive network that inhibits an antitumor immune response. We summarize available data on the effects of immunosuppressive cytokines on T-cell activation and cellular factors that promote cell proliferation in CC patients; also, the functional consequences of HPV proteins interaction on IL-10 and TGF-β1 promoters in the cellular immune response in CC patients.
Last update: 3 April 2013