Special Issue "Ochratoxins"

Guest Editor
Prof. Dr. Richard A. Manderville
Department of Chemistry and Toxicology, University of Guelph, Guelph, Ontario, N1G 2W1 Canada
Website: http://www.chemistry.uoguelph.ca/manderville/webpage.htm
E-Mail:
Phone: +1 519 824 4120
Fax: +1 519 766 1499
Interests: DNA damage by phenolic toxins including ochratoxin A; Modified DNA bases as fluorescent probes

Guest Editor
Prof. Dr. Annie Pfohl-Leszkowicz
National Agronomical High School of Toulouse (ENSAT), Unit of Toxicology & Food safety, 1 avenue de l’Agrobiopôle, BP 32607, 31326, Auzeville-Tolosane, France
E-Mail:
Phone: + 33 562 193 947
Fax: + 33 562 193 947
Interests: mycotoxin; ochratoxin; fumonisin; zearalenone; biomarker; risk evaluation; environmental toxicology; polycyclic aromatic compounds; genotoxicity; DNA adduct; balkan endemic nephropathy; kidney cancer; biotransformation

Dear Colleagues,

In the seminal paper published in Nature, 1965, van Der Merwe, Steyn, Fourie, Scott and Theron, reported the isolation of a new toxic metabolite, called ochratoxin A (now abbreviated OTA), from Aspergillus ochraceus. Structural analysis of the mycotoxin pointed to the presence of a chlorophenolic moiety containing a dihydroisocoumarin system amide-linked to L-phenylalanine with toxicity in ducklings of the same order as that of aflatoxin B1 from Aspergillus flavus. Subsequent experimental carcinogenicity studies in male rats and mice carried out in the 1980s demonstrated OTA to be a potent kidney carcinogen and highlighted the real possibility that OTA could be a human carcinogen. OTA causes kidney damage in farm animals and a number of studies also suggested a correlation between OTA exposure and a fatal human kidney disease called Balkan endemic nephropathy, in which patients exhibit a high incidence of urinary tract tumours. OTA is now regarded as the most toxic member of the ochratoxins, which have attracted considerable attention since they are one of the most abundant food-contaminating mycotoxins in the world and are classified as potentially carcinogenic to humans (Group 2B). Ongoing interdisciplinary research on the ochratoxins have been concerned with detection in feed and human foodstuff, occurrence and estimation of dietary intake, establishment of limits for human consumption based on risk assessment and understanding mechanisms of toxicity and carcinogenicity for the development of detoxification processes. We hope that this special issue of Toxins entitled “Ochratoxins” will provide the readership with a better understanding of the key issues being addressed at the present time.

Prof. Dr. Richard A. Manderville
Prof. Dr. Annie Pfohl-Leszkowicz
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 500 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.

Related Special Issues in other Journals

Ochratoxins 2011 in Toxins

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 500 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.

• ochratoxins
• mycotoxin
• carcinogen
• Balkan endemic nephropathy
• DNA damage
• genotoxic
• intake
• biotransformation
• risk assessment