Special Issue "Nanoparticle-Based Biosensors"

Guest Editor
Prof. Dr. Evangelyn C. Alocilja
Nano-Biosensors Lab, Department of Biosystems and Agricultural Engineering Michigan State University, 524 S. Shaw Lane, Room 115, Farrall Agricultural Engineering Hall, East Lansing, MI 48824-1323, USA
Website: http://www.egr.msu.edu/~alocilja/Research.html
E-Mail: alocilja@msu.edu
Phone: +1-517-432-8672
Interests: nano-enabled biosensing, nanoparticles; nanowires, elecrochemical sensing approaches; infectious diseases; global health; food/water safety; biodefense; product integrity

Dear Colleagues,

This Special Issue will cover biosensing technologies based on nanoparticles of all forms, for a variety of detection and diagnostic applications: infectious and chronic diseases, biomarker monitoring and discovery, pathogen contamination in food and the environment, drug compliance monitoring, plant and animal disease monitoring, epidemiological assessment, product integrity and authentication, bio-energy quality monitoring, and many other applications. Biological receptors may include antibodies, DNA probes, aptamers, enzymes, molecularly imprinted polymers, glycoproteins, and many other forms of target recognition. Detection modalities may include optical, electrical, electrochemical, acoustic waves, magnetic, and other forms and combinations of signal generation. Microfluidics, lab-on-chip, and integrated platforms are most welcome.

Prof. Dr. Evangelyn C. Alocilja
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).

• rapid detection
• early diagnosis
• affordable devices
• simple techniques
• point-of-care
• infectious diseases
• chronic diseases
• biomarker monitoring and discovery
• pathogen contamination
• drug compliance
• plant and animal diseases
• epidemiological assessment
• product integrity and authentication
• bio-energy quality monitoring

Type of Paper: Review
Title: Silicon Nanomaterials-Based Biosensors
Author: Yao He
Affiliation: Institute of Functional Nano&Soft Materials, Soochow University, Suzhou, China; Tel: 86-512-65880946; Fax: 86-512-65880946; Group website: http://www.sense-group.cn
Abstract: During the past decade, a number of high-performance silicon nanomaterials-based biosensors have been developed for biosensing applications. With an aim to highlight these important and exciting achievements, we herein focus on reviewing the recent representative works of silicon nanomaterials-based biosensors. First, we will briefly review the fabrication of silicon nanomaterials-based sensing devices. Next, we will present their wide-ranging biosensing applications. Finally, we will discuss their major challenges and future prospects.

Type of Paper: Article
Title: Magnetic Bead-Based Immunoassay for Aflatoxin B1 via Inner Filter Effect of Gold Nanoparticles.
Authors: Xu Wang, Reinhard Niessner and Dietmar Knopp
Affiliations: Chair for Analytical Chemistry, Institute of Hydrochemistry, Technische Universität München, Marchioninistrasse 17, D-81377 Munich, Germany
E-mail: Dietmar.Knopp@ch.tum.de
Abstract: A simple, rapid and sensitive fluorescence immunoassay for the detection of aflatoxin B1 (AFB) has been developed, which is based on the fluorescence quenching of fluorescein caused by gold nanoparticles via inner filter effect. As immunosensing probe magnetic beads were coated with aflatoxin B1-bovine serum albumin conjugates, anti-AFB antibodies coated gold nanoparticles could bind with the magnetic beads through the antibody–antigen reaction; while such binding was competitively inhibited by the addition of AFB. After magnetic separation, the supernatant, which contained the unbound gold nanoparticles, was utilized to quench the fluorescence of fluorescein. The fluorescence intensity at 510 nm was inversely proportional to the AFB concentration. This method could be easily extended to detect other mycotoxins and organic pollutants.