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Polymers
Special Issues
Bioactive and Biofunctional Conductive Polymers
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Bioactive and Biofunctional Conductive Polymers

A special issue of Polymers (ISSN 2073-4360).

Deadline for manuscript submissions: closed (20 November 2018)

Special Issue Editor

Dr. Rylie A. Green

E-Mail Website
Guest Editor
Department of Bioengineering, Imperial College London, London SW72BX, UK
Interests: bio-interfacial engineering for neuroprosthetics; polymer-based electronics; biomaterials for regenerative medicine

Special Issue Information

Dear Colleagues,

Research and development of conductive polymer technologies for medical devices and sensors have demonstrated their significant potential. Specifically, they have been shown to improve on conventional metallic and semiconductor technologies. This Special Issue will focus on the ways in which conductive polymers have been modified to improve their biological interactions with target tissues. This will encompass chemical and physical approaches, including the use of biomolecules, biomimetic inclusions, non-conductive polymer composites and novel structuring methods. Studies that demonstrate translation of bench studies to the in vitro and in vivo environment will be presented, as they are critical to demonstration of biofunctionality.

Dr. Rylie A. Green
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • conductive polymer
  • bioactivity
  • biofunctionality
  • peptides
  • growth factors
  • biomimetics
  • nanostructures
  • hydrogel
  • flexible
  • sensors
  • implants

Published Papers (3 papers)

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Research

14 pages, 4877 KiB  
Article
Glucose Oxidase Immobilized on a Functional Polymer Modified Glassy Carbon Electrode and Its Molecule Recognition of Glucose
by Yan-Na Ning, Bao-Lin Xiao, Nan-Nan Niu, Ali Akbar Moosavi-Movahedi and Jun Hong
Polymers 2019, 11(1), 115; https://doi.org/10.3390/polym11010115 - 11 Jan 2019
Cited by 15 | Viewed by 4643
Abstract
In the present study, a glucose oxidase (GluOx) direct electron transfer was realized on an aminated polyethylene glycol (mPEG), carboxylic acid functionalized multi-walled carbon nanotubes (fMWCNTs), and ionic liquid (IL) composite functional polymer modified glassy carbon electrode (GCE). The amino groups in PEG, [...] Read more.
In the present study, a glucose oxidase (GluOx) direct electron transfer was realized on an aminated polyethylene glycol (mPEG), carboxylic acid functionalized multi-walled carbon nanotubes (fMWCNTs), and ionic liquid (IL) composite functional polymer modified glassy carbon electrode (GCE). The amino groups in PEG, carboxyl groups in multi-walled carbon nanotubes, and IL may have a better synergistic effect, thus more effectively adjust the hydrophobicity, stability, conductivity, and biocompatibility of the composite functional polymer film. The composite polymer membranes were characterized by cyclic voltammetry (CV), ultraviolet-visible (UV-Vis) spectrophotometer, fluorescence spectroscopy, electrochemical impedance spectroscopy (EIS), and transmission electron microscopy (TEM), respectively. In 50 mM, pH 7.0 phosphate buffer solution, the formal potential and heterogeneous electron transfer constant (ks) of GluOx on the composite functional polymer modified GCE were −0.27 V and 6.5 s−1, respectively. The modified electrode could recognize and detect glucose linearly in the range of 20 to 950 μM with a detection limit of 0.2 μM. The apparent Michaelis-Menten constant (Kmapp) of the modified electrode was 143 μM. The IL/mPEG-fMWCNTs functional polymer could preserve the conformational structure and catalytic activity of GluOx and lead to high sensitivity, stability, and selectivity of the biosensors for glucose recognition and detection. Full article
(This article belongs to the Special Issue Bioactive and Biofunctional Conductive Polymers)
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13 pages, 2830 KiB  
Article
The Synergistic Effects of Gold Particles and Dexamethasone on the Electrochemical and Biological Performance of PEDOT Neural Interfaces
by Katarzyna Krukiewicz, Magdalena Chudy, Stephen Gregg and Manus J. P. Biggs
Polymers 2019, 11(1), 67; https://doi.org/10.3390/polym11010067 - 05 Jan 2019
Cited by 12 | Viewed by 3919
Abstract
Although neural devices have shown efficacy in the treatment of neurodegenerative diseases, their functionality is limited by the inflammatory state and glial scar formation associated with chronic implantation. The aim of this study was to investigate neural electrode performance following functionalization with an [...] Read more.
Although neural devices have shown efficacy in the treatment of neurodegenerative diseases, their functionality is limited by the inflammatory state and glial scar formation associated with chronic implantation. The aim of this study was to investigate neural electrode performance following functionalization with an anti-inflammatory coating derived from a conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) matrix doped with dexamethasone (Dex) and decorated with Au particles. Pristine PEDOT, PEDOT-Dex and their gold-decorated analogues (PEDOT/Au and PEDOT-Dex/Au) were formulated by electrochemical deposition and characterized with respect to electrode electrochemical properties, surface morphology and biocompatibility towards primary neural cells. Through a process of gold deposition, it was possible to eliminate the initial burst release observed in PEDOT-Dex and maintain a stable, stepwise increase in Dex elution over 7 days. The released amounts of Dex exceeded the concentrations considered as therapeutic for both PEDOT-Dex and PEDOT-Dex/Au. The results clearly indicated that the presence of either Dex or Au particles facilitated the outgrowth of neurites. Finally, it was shown that the application of composite materials, such as PEDOT-Dex/Au, is an efficient way to improve the efficacy of neural interfaces in vitro. Full article
(This article belongs to the Special Issue Bioactive and Biofunctional Conductive Polymers)
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16 pages, 4069 KiB  
Article
Detection of Acidic Pharmaceutical Compounds Using Virus-Based Molecularly Imprinted Polymers
by In-Hyuk Baek, Hyung-Seop Han, Seungyun Baik, Volkhard Helms and Youngjun Kim
Polymers 2018, 10(9), 974; https://doi.org/10.3390/polym10090974 - 01 Sep 2018
Cited by 10 | Viewed by 3785
Abstract
Molecularly imprinted polymers (MIPs) have proven to be particularly effective chemical probes for the molecular recognition of proteins, DNA, and viruses. Here, we started from a filamentous bacteriophage to synthesize a multi-functionalized MIP for detecting the acidic pharmaceutic clofibric acid (CA) as a [...] Read more.
Molecularly imprinted polymers (MIPs) have proven to be particularly effective chemical probes for the molecular recognition of proteins, DNA, and viruses. Here, we started from a filamentous bacteriophage to synthesize a multi-functionalized MIP for detecting the acidic pharmaceutic clofibric acid (CA) as a chemical pollutant. Adsorption and quartz crystal microbalance with dissipation monitoring experiments showed that the phage-functionalized MIP had a good binding affinity for CA, compared with the non-imprinted polymer and MIP. In addition, the reusability of the phage-functionalized MIP was demonstrated for at least five repeated cycles, without significant loss in the binding activity. The results indicate that the exposed amino acids of the phage, together with the polymer matrix, create functional binding cavities that provide higher affinity to acidic pharmaceutical compounds. Full article
(This article belongs to the Special Issue Bioactive and Biofunctional Conductive Polymers)
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