Drug Metabolism and Pharmacokinetics

A special issue of Pharmaceutics (ISSN 1999-4923).

Deadline for manuscript submissions: closed (30 April 2015) | Viewed by 8249

Special Issue Editor

Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL 33612, USA
Interests: drug discovery; systems pharmacology; cancer pharmacology; drug metabolism and transport; pharmacometrics; pharmacogenomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, “Drug Metabolism and Pharmacokinetics”, will address the main aspects of drug metabolism and the pharmacokinetics of new and existing drugs. In drug development, Absorption, Distribution, Metabolism, and Excretion (ADME) are some of the most important aspects of a drug that a scientist must know of. The topics of papers submitted to this Special Issue can be about drug methods, models, and their applications, drug mechanisms, regulation (of drugs) by both genetic and epigenetic factors, and the clinical and toxicological data concerning drug metabolism and pharmacokinetic studies. Translational and clinical studies on important drug metabolizing enzymes and drug transporters will also be considered.

Prof. Dr. Shufeng Zhou
Guest Editors

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Keywords

  • drug metabolism
  • pharmacokinetics
  • regulation
  • cytochrome P450
  • drug transporter
  • drug-drug interaction
  • toxicity
  • drug response
  • metabolic pathway
  • molecular modeling
  • drug development

Published Papers (1 paper)

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Research

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Article
Influence of Differing Analgesic Formulations of Aspirin on Pharmacokinetic Parameters
by Kunal Kanani, Sergio C. Gatoulis and Michael Voelker
Pharmaceutics 2015, 7(3), 188-198; https://doi.org/10.3390/pharmaceutics7030188 - 03 Aug 2015
Cited by 20 | Viewed by 7738
Abstract
Aspirin has been used therapeutically for over 100 years. As the originator and an important marketer of aspirin-containing products, Bayer’s clinical trial database contains numerous reports of the pharmacokinetics of various aspirin formulations. These include evaluations of plain tablets, effervescent tablets, granules, chewable [...] Read more.
Aspirin has been used therapeutically for over 100 years. As the originator and an important marketer of aspirin-containing products, Bayer’s clinical trial database contains numerous reports of the pharmacokinetics of various aspirin formulations. These include evaluations of plain tablets, effervescent tablets, granules, chewable tablets, and fast-release tablets. This publication seeks to expand upon the available pharmacokinetic information concerning aspirin formulations. In the pre-systemic circulation, acetylsalicylic acid (ASA) is rapidly converted into its main active metabolite, salicylic acid (SA). Therefore, both substances are measured in plasma and reported in the results. The 500 mg strength of each formulation was chosen for analysis as this is the most commonly used for analgesia. A total of 22 studies were included in the analysis. All formulations of 500 mg aspirin result in comparable plasma exposure to ASA and SA as evidenced by AUC. Tablets and dry granules provide a consistently lower Cmax compared to effervescent, granules in suspension and fast release tablets. Effervescent tablets, fast release tablets, and granules in suspension provide a consistently lower median Tmax compared to dry granules and tablets for both ASA and SA. This report reinforces the importance of formulation differences and their impact on pharmacokinetic parameters. Full article
(This article belongs to the Special Issue Drug Metabolism and Pharmacokinetics)
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