Special Issue "Drug Metabolism and Pharmacokinetics"

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A special issue of Pharmaceutics (ISSN 1999-4923).

Deadline for manuscript submissions: closed (30 April 2015)

Special Issue Editor

Guest Editor
Prof. Dr. Shufeng Zhou (Website)

Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida, USA
Interests: drug discovery; systems pharmacology; cancer pharmacology; drug metabolism and transport; pharmacometrics; pharmacogenomics

Special Issue Information

Dear Colleagues,

This Special Issue, “Drug Metabolism and Pharmacokinetics”, will address the main aspects of drug metabolism and the pharmacokinetics of new and existing drugs. In drug development, Absorption, Distribution, Metabolism, and Excretion (ADME) are some of the most important aspects of a drug that a scientist must know of. The topics of papers submitted to this Special Issue can be about drug methods, models, and their applications, drug mechanisms, regulation (of drugs) by both genetic and epigenetic factors, and the clinical and toxicological data concerning drug metabolism and pharmacokinetic studies. Translational and clinical studies on important drug metabolizing enzymes and drug transporters will also be considered.

Prof. Dr. Shufeng Zhou
Guest Editors

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 500 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.

Keywords

  • drug metabolism
  • pharmacokinetics
  • regulation
  • cytochrome P450
  • drug transporter
  • drug-drug interaction
  • toxicity
  • drug response
  • metabolic pathway
  • molecular modeling
  • drug development

Published Papers (1 paper)

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Research

Open AccessArticle Influence of Differing Analgesic Formulations of Aspirin on Pharmacokinetic Parameters
Pharmaceutics 2015, 7(3), 188-198; doi:10.3390/pharmaceutics7030188
Received: 25 June 2015 / Revised: 29 July 2015 / Accepted: 29 July 2015 / Published: 3 August 2015
Cited by 2 | PDF Full-text (1330 KB) | HTML Full-text | XML Full-text
Abstract
Aspirin has been used therapeutically for over 100 years. As the originator and an important marketer of aspirin-containing products, Bayer’s clinical trial database contains numerous reports of the pharmacokinetics of various aspirin formulations. These include evaluations of plain tablets, effervescent tablets, granules, [...] Read more.
Aspirin has been used therapeutically for over 100 years. As the originator and an important marketer of aspirin-containing products, Bayer’s clinical trial database contains numerous reports of the pharmacokinetics of various aspirin formulations. These include evaluations of plain tablets, effervescent tablets, granules, chewable tablets, and fast-release tablets. This publication seeks to expand upon the available pharmacokinetic information concerning aspirin formulations. In the pre-systemic circulation, acetylsalicylic acid (ASA) is rapidly converted into its main active metabolite, salicylic acid (SA). Therefore, both substances are measured in plasma and reported in the results. The 500 mg strength of each formulation was chosen for analysis as this is the most commonly used for analgesia. A total of 22 studies were included in the analysis. All formulations of 500 mg aspirin result in comparable plasma exposure to ASA and SA as evidenced by AUC. Tablets and dry granules provide a consistently lower Cmax compared to effervescent, granules in suspension and fast release tablets. Effervescent tablets, fast release tablets, and granules in suspension provide a consistently lower median Tmax compared to dry granules and tablets for both ASA and SA. This report reinforces the importance of formulation differences and their impact on pharmacokinetic parameters. Full article
(This article belongs to the Special Issue Drug Metabolism and Pharmacokinetics)
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