Special Issue "Transporter-Mediated Drug Interactions"

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A special issue of Pharmaceutics (ISSN 1999-4923).

Deadline for manuscript submissions: closed (31 May 2011)

Special Issue Editor

Guest Editor
Dr. Constanze Hilgendorf
Innovative Medicines and Early Development, Drug Safety and Metabolism, DMPK, AstraZeneca R&D Mölndal, S-431 83 Mölndal, Sweden
E-Mail: constanze.hilgendorf@astrazeneca.com
Phone: +46 31 706 53 49
Fax: +46 31 776 37 86
Interests: drug transporters in ADME; in-vitro and in-vivo transporter profiling; drug-drug interactions; drug absorption; intestinal metabolism

Special Issue Information

Dear Colleagues,

Advances in the field of in-vitro tools to accurately describe NME’s interactions with enzymes and transport proteins have led to an improved qualitative understanding of putative interaction points and elimination pathways of the NME. Additionally, more sophisticated in vivo methods (KO or humanized animals) are explored and an increasing number of clinical examples of transporter and transporter/enzyme mediated interactions are reported. Scientific and technological development impacts furthermore on the regulatory views on drug interactions. This special issue highlights advances in in vitro and in vivo studies to mechanistically describe drug-transporter interactions and the complementary modeling approaches to quantitatively predict clinical consequences of such interactions. We invite articles covering all aspects from in-vitro work to modeling and clinical interaction studies.

Dr. Constanze Hilgendorf
Guest Editor

Keywords

  • ABC-transporters
  • SLC-transporters
  • vectorial transport
  • enzyme-transporter interplay
  • inhibition
  • induction
  • pharmacogenomics
  • intestine
  • liver
  • kidney
  • blood-brain-barrier

Published Papers (1 paper)

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p. 782-792
by , , , , ,  and
Pharmaceutics 2011, 3(4), 782-792; doi:10.3390/pharmaceutics3040782
Received: 22 September 2011; in revised form: 11 October 2011 / Accepted: 20 October 2011 / Published: 27 October 2011
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Last update: 4 March 2014

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