Special Issue "Transporter-Mediated Drug Interactions"
A special issue of Pharmaceutics (ISSN 1999-4923).
Deadline for manuscript submissions: closed (31 May 2011)
Dr. Constanze Hilgendorf
DiscoveryDMPK, AstraZeneca R&D, Mölndal, S-431 83 Mölndal, Sweden
Phone: +46 31 706 53 49
Fax: +46 31 776 37 86
Interests: drug transporters in ADME; in-vitro and in-vivo transporter profiling; drug-drug interactions; drug absorption; intestinal metabolism
Advances in the field of in-vitro tools to accurately describe NME’s interactions with enzymes and transport proteins have led to an improved qualitative understanding of putative interaction points and elimination pathways of the NME. Additionally, more sophisticated in vivo methods (KO or humanized animals) are explored and an increasing number of clinical examples of transporter and transporter/enzyme mediated interactions are reported. Scientific and technological development impacts furthermore on the regulatory views on drug interactions. This special issue highlights advances in in vitro and in vivo studies to mechanistically describe drug-transporter interactions and the complementary modeling approaches to quantitatively predict clinical consequences of such interactions. We invite articles covering all aspects from in-vitro work to modeling and clinical interaction studies.
Dr. Constanze Hilgendorf
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 500 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- vectorial transport
- enzyme-transporter interplay
Pharmaceutics 2011, 3(4), 782-792; doi:10.3390/pharmaceutics3040782
Received: 22 September 2011; in revised form: 11 October 2011 / Accepted: 20 October 2011 / Published: 27 October 2011| Download PDF Full-text (494 KB) | Download XML Full-text
Last update: 27 March 2013