Special Issue "Prodrugs"
A special issue of Pharmaceuticals (ISSN 1424-8247).
Deadline for manuscript submissions: closed (15 January 2014)
Prof. Dr. Jarkko Rautio
School of Pharmacy Faculty of Health Sciences University of Eastern Finland P.O.Box 1627 FI-70211 Kuopio Finland
Phone: +358 040 3532791
Interests: prodrugs; CNS drug delivery; drug transporters
Dr. Kristiina Huttunen
School of Pharmacy Faculty of Health Sciences University of Eastern Finland P.O.Box 1627 FI-70211 Kuopio, Finland
Interests: design and discovery of prodrugs; perforin inhibitors
We would like to invite you to submit an original manuscript, communication or review for this special issue. Your contribution to this topic will greatly enhance the understanding of this important topic to the readers of Pharmaceuticals. We would like the focus of this issue to be on the structure-activity relationships between promoiety structure and absorption, targeting and/or activation. Additional focus on the physicochemical changes that the prodrug moiety adds to the molecule and how that results in different PK, distribution kinetics and toxicities are also welcome.
Prof. Dr. Jarkko Rautio
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed Open Access monthly journal published by MDPI.
Pharmaceuticals 2014, 7(7), 797-838; doi:10.3390/ph7070797
Received: 3 April 2014; in revised form: 17 June 2014 / Accepted: 18 June 2014 / Published: 10 July 2014| PDF Full-text (2242 KB) | HTML Full-text | XML Full-text
Article: Conformational Analysis, Molecular Structure and Solid State Simulation of the Antiviral Drug Acyclovir (Zovirax) Using Density Functional Theory Methods
Pharmaceuticals 2014, 7(6), 695-722; doi:10.3390/ph7060695
Received: 16 January 2014; in revised form: 22 May 2014 / Accepted: 26 May 2014 / Published: 6 June 2014| PDF Full-text (1903 KB) | HTML Full-text | XML Full-text | Supplementary Files
Pharmaceuticals 2014, 7(6), 676-694; doi:10.3390/ph7060676
Received: 13 March 2014; in revised form: 15 May 2014 / Accepted: 19 May 2014 / Published: 28 May 2014| PDF Full-text (592 KB) | HTML Full-text | XML Full-text | Supplementary Files
Article: Synthesis, Screening and Pharmacokinetic Evaluation of Potential Prodrugs of Bupropion. Part One: In Vitro Development
Pharmaceuticals 2014, 7(5), 595-620; doi:10.3390/ph7050595
Received: 13 March 2014; in revised form: 30 April 2014 / Accepted: 8 May 2014 / Published: 14 May 2014| PDF Full-text (653 KB) | HTML Full-text | XML Full-text | Supplementary Files
Article: Amino Acid Prodrugs: An Approach to Improve the Absorption of HIV-1 Protease Inhibitor, Lopinavir
Pharmaceuticals 2014, 7(4), 433-452; doi:10.3390/ph7040433
Received: 23 January 2014; in revised form: 24 March 2014 / Accepted: 31 March 2014 / Published: 10 April 2014| PDF Full-text (419 KB) | HTML Full-text | XML Full-text | Supplementary Files
Article: Design of Prodrugs to Enhance Colonic Absorption by Increasing Lipophilicity and Blocking Ionization
Pharmaceuticals 2014, 7(2), 207-219; doi:10.3390/ph7020207
Received: 20 January 2014; in revised form: 8 February 2014 / Accepted: 12 February 2014 / Published: 24 February 2014| PDF Full-text (128 KB) | HTML Full-text | XML Full-text
Article: The Dipeptide Monoester Prodrugs of Floxuridine and Gemcitabine—Feasibility of Orally Administrable Nucleoside Analogs
Pharmaceuticals 2014, 7(2), 169-191; doi:10.3390/ph7020169
Received: 26 November 2013; in revised form: 15 January 2014 / Accepted: 22 January 2014 / Published: 27 January 2014| PDF Full-text (514 KB) | HTML Full-text | XML Full-text | Supplementary Files
Last update: 11 July 2014