Special Issue "Antihypertensive Drugs"

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A special issue of Pharmaceuticals (ISSN 1424-8247).

Deadline for manuscript submissions: closed (30 November 2009)

Special Issue Editors

Guest Editor
Prof. Dr. Giuseppe Mancia
Clinical Medicine Unit, University of Milano-Bicocca, San Gerardo Hospital, Via Pergolesi, 33, 20052 Monza (MI), Italy
E-Mail:
Phone: +39 039 2333357
Fax: +39 039 322274
Interests: pathophysiology; clinical pharmacology and therapy of hypertension; congestive heart failure and other cardiovascular diseases

Guest Editor
Prof. Dr. Guido Grassi
Dipartimento di Medicina Clinica, Università Milano-Bicocca, Ospedale San Gerardo di Monza, Italy
E-Mail:

Published Papers

Click here to see a list of 17 papers that have been published in this special issue.

Special Issue Information

Dear Colleagues,

Hypertension has not always been recognized as a harbinger of cardiovascular complications and premature death. Only 70 years ago, hypertension was considered the body\'s adaptation to sclerotic blood vessel disease and essential to maintain organ perfusion; thus, treatment was regarded as undesirable. Epidemiologic studies have since established a strong linear relation between blood pressure and cardiovascular disease (CVD), and randomized trials have documented that blood pressure reductions by antihypertensive drugs confer cardiovascular protection, making the hypertension-related risk a reversible risk. There is now a consensus that blood pressure should be reduced to <140/90 mm Hg in all patients and that a more aggressive blood pressure target (<130/80 mm Hg) should be pursued in those in whom the cardiovascular risk is high. Despite this, blood pressure control remains elusive in most individuals in the hypertensive population, which makes improvement of blood pressure control in this population a priority goal. This goal may meet with new challenges, however. Optimal blood pressure control may have to include the measurement of blood pressure every day, given the fluctuations of blood pressure and their prognostic importance independent of and in addition to that of classically measured blood pressure values. This special issue of the journal will provide an up-to-date and comprehensive review of the drugs currently used in antihypertensive treatment.

Prof. Dr. Guido Grassi
Guest Editor

Submission Information

All papers should be submitted to pharmaceuticals@mdpi.com. To be published continuously until the deadline and papers will be listed together at the special issue website.

Submitted papers should not have been published nor be under consideration for publication elsewhere. All papers are refereed through a peer-review process. A guide for authors is available on the Instructions for Authors page. Pharmaceuticals is a new international, peer-reviewed, quarterly open access journal published by MDPI.

Article Processing Charges (APC) for publication in this open access journal are waived for well-prepared manuscripts submitted by 30 June 2010. English correction or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those paper accepted for publication, that require extensive additional formatting and/or English corrections.

Keywords

  • hypertension
  • antihypertensive treatment
  • ace-inhibitors
  • angiotensin II receptor blockers
  • diuretics
  • calcium antagonists
  • beta-blockers
  • blood pressure control
  • cardiovascular risk
  • clinical trials

Planned Papers

Manuscript ID: Pharmaceuticals-Antihyper-20090619- Khoynezhad-us
Type of Paper: Review
Title: Hypertensive Emergency in Aortic Dissection and Thoracic Aortic Aneurysm – a Review of Management
Authors: Prateek K. Gupta1, Himani Gupta2, Ali Khoynezhad1.*
1 Department of Surgery, Creighton University Medical Center, Omaha, NE 68131
2 Department of Medicine, Creighton University Medical Center, Omaha, NE 68131
Email: akhoy@creighton.edu
Abstract: Over the last few decades, treatment for aortic dissection and thoracic aortic aneurysms has significantly evolved with improvement in outcomes. Treatment paradigm include medical, endovascular and surgical options. As aortic dissection presents as hypertensive emergency, it is imperative to control the blood pressure so as to prevent the progression of dissection and associated complications. Diligent control of BP is of utmost importance in order to stop the progression of dissection with possible aortic branch malperfusion. Treatment should begin on arrival to the emergency department and continues in the intensive care unit, endovascular suite or the operating room. Novel antihypertensive medications with improved pharmacological profile and improved surgical techniques, have improved the prognosis of patients with aortic aneurysm and/or aortic dissection. However, morbidity and mortality remain high and hypertensive emergency poses a significant challenge in aortic dissection and thoracic aortic aneurysms.

Manuscript ID: Pharmaceuticals- Antihyper-20090704-Semplicini-it

Title: Obsessive-Compulsive and Post Traumatic Avoidance Symptoms Influence the Response to Antihypertensive Therapy: Relevance in Uncontrolled Hypertension
Type of Paper: Article
Authors: A. Realdi MD 1; A. Favaro MD 2; P. Santonastaso MD 2; M. Nuti MD 2; E. Parotto MD 1; G. Inverso MD 1 ; M. Leoni MD 1; L. Macchini MD 1; F. Vettore MD 1; L.A. Calo\' MD PhD 1; and A. Semplicini MD1,3,*
1 Department of Clinical and Experimental Medicine, University of Padua
2 Department of Neuroscience, University of Padua
3 Internal Medicine, SS. Giovanni e Paolo Hospital, Venice, Italy
* Author and Address for correspondence: UOC Medicina Generale, Ospedale SS. Giovanni e Paolo, Campo SS. Giovanni e Paolo, Castello 6777 – I-30122 Venezia; voice. +39 041 5294360; +39 041 5295556; Fax: +39041 5294651; E-mail andrea.semplicini@ulss12.ve.it
Abstract: Background: Uncontrolled hypertension is a clinical problem carrying high cardiovascular risk. Aim of the study was to investigate the association of uncontrolled hypertension with psychological factors associated with high cardiovascular morbidity and mortality (type D personality, depression, posttraumatic stress-related symptoms).
Methods: 205 consecutive hypertensive patients, attending an hypertension outpatient clinic, completed three questionnaires evaluating Type D personality (DS 16), post traumatic symptoms (revised Impact of Events Scale), symptoms of anxiety, hostility, depression and obsessive-compulsive traits (subscales of the Symptom Checklist). Uncontrolled hypertension was diagnosed when clinic sitting blood pressure was above 140/90 mmHg (130/80 in the presence of diabetes or nephropathy), despite reported adherence to treatment with at least three antihypertensive medications, including a diuretic.
Results: Uncontrolled hypertension (38.5% of the cohort), besides being associated with older age, diabetes, higher systolic pressure at first visit and longstanding hypertension, was predicted by lower scores at Symptom Checklist obsessive-compulsive subscale and higher number of post traumatic avoidance symptoms upon logistic regression analysis. Type D personality correlated with depression, hostility, anxiety, compulsiveness, history of malignancy, and older age, but not with uncontrolled hypertension.
Conclusions: The association between uncontrolled hypertension and low obsessionality and avoidance symptoms suggests that these personality traits affect response to antihypertensive treatment, most likely by reducing compliance. On the contrary, type D personality is not correlated with uncontrolled hypertension, as it includes compulsiveness, a protective psychological factor that improves compliance. A multidisciplinary approach to the hypertensive patient is mandatory to establish cardiovascular and psychological risk factors that could affect compliance and raise emotional stress.

Last update: 26 March 2010

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