Special Issue "Antibiotics"

Guest Editor
Dr. Mark C. Bagley
School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff, CF10 3AT, Wales, UK
Website: http://www.cardiff.ac.uk/chemy/staff/bagley.html
E-Mail:
Interests: Heterocyclic chemistry, synthetic chemistry and ageing research, synthetic chemistry and tissue engineering, synthetic chemistry and cell signalling, synthetic chemistry and chemical engineering, Microwave- assisted synthesis and methodology

Guest Editor
Dr. John Spencer
University of Greenwich at Medway, Chatham ME4 4TB, UK
E-Mail:

Dear Colleagues,

Antibiotics are central to healthcare, society and medicinal chemistry and the field is constantly evolving, in tandem with the bacteria that they aim to eradicate. The constant challenges facing us still pertain to the effectiveness of these agents in disease treatment and management to lessen the heavy burden on society. As a leading scientist in this area, we invite you to contribute an article, review or communication to this special edition on “Antibiotics” with specific relevance to the antibiotics field. Specific topics include, but are not limited to: prevention, new therapeutic agents, drug discovery, diagnostics and drug resistance.

Dr. Mark C. Bagley
Guest Editor

Dr. John Spencer
Guest Editor

Submission

All manuscripts should be submitted to pharmaceuticals@mdpi.com with a copy to the Guest Editor. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed Open Access monthly journal published by MDPI.

• antibacterial activity
• bacterial metabolism and biosynthesis
• bacterial resistance
• clinical trials
• combinatorial libraries
• drug discovery
• medicinal chemistry
• mode of action
• natural products
• screening
• quorum sensing

Manuscript ID: Pharmaceuticals-antibiotics-20091110-Di Stefano-it
Type of Paper: Review
Title: Rational Use of Antibiotics in the Treatment of Functional Bowel Disorders
Authors: M. Di Stefano, C. Mengoli and G.R. Corazza
Affiliation: Department of Medicine, University of Pavia, Foundation IRCCS “S.Matteo” Hospital, Piazzale Camillo Golgi 19, Pavia 27100, Italy; E-Mail: m.distefano@smatteo.pv.it
Abstract: Functional gastrointestinal symptoms such us bloating, fullness, flatulence, diarrhea, and constipation due to irritable bowel syndrome (IBS) were recently erroneously attributed to small bowel bacterial overgrowth, a condition depending on the presence of an increased number of bacteria in the small bowel. This association provoked an incorrect use of antibiotics. However, antibiotics could be effective in the treatment of functional complaints, but only in a subgroup of patients, characterized by an increase of fermentation at colonic level. In this review, we have commented on the rationale for antibiotic use in IBS and revised the papers suggesting the incorrect pathophysiological link between IBS and small bowel bacterial overgrowth.