Special Issue "Infection and Cancer"
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (29 June 2012)
Prof. Dr. Lawrence S. Young
Research (Life Sciences and Medicine) and Capital Development, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
Phone: +44 1214 146876
Interests: viral oncology; virus latency; viral immunology; gene therapy; herpesviruses; papillomaviruses; adenoviruses
It is estimated that infection contributes to the development of around 20% of human cancer – some 2 million cases per year. Understanding the role of infection in cancer continues to provide fundamental insights into the underlying mechanisms responsible for driving the oncogenic process as well as highlighting opportunities for therapeutic and prophylactic intervention. It is just over 100 years since Peyton Rous discovered an infectious agent capable of transmitting sarcoma to chickens. This observation spawned the field of tumour virology resulting in a range of key discoveries including the identification of oncogenes and of viruses associated with human cancer. In the last few years the significance of infection-related cancer has been recognized by the award of the Nobel prize in Physiology or Medicine. In 2005 the Nobel prize was awarded to Barry Marshall and Robin Warren for their discovery of Helicobacter pylori, the bacterium associated with peptic ulcers, gastritis and gastric cancer. And in 2008 Harald zur Hausen was awarded the Nobel prize for his discovery of human papillomaviruses and their association with cervical cancer. Both these seminal observations have not only shed light on different oncogenic mechanisms but led to exciting cancer prevention approaches based on eradicating infection – antibiotics in the case of Helicobacter pylori and vaccination in the case of human papillomavirus. The special issue on ‘Infection and Cancer’ will focus on the current status of our understanding of the role of infectious agents in the etiology of human cancer and on the opportunities for therapeutic and prophylactic intervention. We thus invite submission of research and review manuscripts that cover any aspect of the epidemiology, molecular and cell biology, immunology, diagnosis, treatment and prevention of infection-related cancer. I look forward to your contributions and to a valuable edition that will promote further developments in this exciting field.
Thank you for your collaboration.
Prof. Dr. Lawrence S. Young
- infectious agents
- tumour viruses
- tumour immunology
Pathogens 2012, 1(2), 156-174; doi:10.3390/pathogens1020156
Received: 10 October 2012; in revised form: 16 October 2012 / Accepted: 30 October 2012 / Published: 8 November 2012| Cited by 1 | PDF Full-text (309 KB) | HTML Full-text | XML Full-text
Review: Exploitation of Cellular Cytoskeletons and Signaling Pathways for Cell Entry by Kaposi’s Sarcoma-Associated Herpesvirus and the Closely Related Rhesus Rhadinovirus
Pathogens 2012, 1(2), 102-127; doi:10.3390/pathogens1020102
Received: 2 September 2012; in revised form: 11 October 2012 / Accepted: 13 October 2012 / Published: 22 October 2012| Cited by 1 | PDF Full-text (317 KB) | HTML Full-text | XML Full-text
Article: Hypomethylation and Over-Expression of the Beta Isoform of BLIMP1 is Induced by Epstein-Barr Virus Infection of B Cells; Potential Implications for the Pathogenesis of EBV-Associated Lymphomas
Pathogens 2012, 1(2), 83-101; doi:10.3390/pathogens1020083
Received: 15 August 2012; in revised form: 19 September 2012 / Accepted: 24 September 2012 / Published: 8 October 2012| PDF Full-text (858 KB) | HTML Full-text | XML Full-text
Article: Chemoresistance to Valproate Treatment of Bovine Leukemia Virus-Infected Sheep; Identification of Improved HDAC Inhibitors
Pathogens 2012, 1(2), 65-82; doi:10.3390/pathogens1020065
Received: 5 September 2012; in revised form: 24 September 2012 / Accepted: 2 October 2012 / Published: 8 October 2012| PDF Full-text (990 KB) | HTML Full-text | XML Full-text
Article: Arginine Methyltransferases Are Regulated by Epstein-Barr Virus in B Cells and Are Differentially Expressed in Hodgkin’s Lymphoma
Pathogens 2012, 1(1), 52-64; doi:10.3390/pathogens1010052
Received: 14 August 2012; in revised form: 28 August 2012 / Accepted: 4 September 2012 / Published: 19 September 2012| PDF Full-text (675 KB) | HTML Full-text | XML Full-text
Review: Similarities between the Epstein-Barr Virus (EBV) Nuclear Protein EBNA1 and the Pioneer Transcription Factor FoxA: Is EBNA1 a “Bookmarking” Oncoprotein that Alters the Host Cell Epigenotype?
Pathogens 2012, 1(1), 37-51; doi:10.3390/pathogens1010037
Received: 2 August 2012; in revised form: 21 August 2012 / Accepted: 4 September 2012 / Published: 17 September 2012| Cited by 3 | PDF Full-text (323 KB) | HTML Full-text | XML Full-text
Article: Evaluation of the Cobas 4800 HPV Test for Detecting High-Risk Human Papilloma-Virus in Cervical Cytology Specimens
Pathogens 2012, 1(1), 30-36; doi:10.3390/pathogens1010030
Received: 12 August 2012; in revised form: 25 August 2012 / Accepted: 31 August 2012 / Published: 12 September 2012| Cited by 1 | PDF Full-text (110 KB) | HTML Full-text | XML Full-text
Last update: 4 March 2014