Special Issue "Quantum Dots for Following Therapeutic Delivery"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 31 December 2017

Special Issue Editor

Guest Editor
Dr. Kevin Critchley

School of Physics and Astronomy, University of Leeds, Leeds, UK
Website | E-Mail
Phone: +44 113 343 3873
Fax: +44 113 343 3900
Interests: quantum dots; nanoparticles; nanowires; self-assembly; self-assembled monolayers; nanorods; nanotubes; photoacoustic imaging; biosensing

Special Issue Information

Dear Colleagues,

Quantum dots are powerful tools for investigating biology. Their bright fluorescence, tuneable emission, functionalizable surfaces, and resistance to bleaching make them exceptional fluorophores. Quantum dots were first reported, in 1998, for biological imaging applications by Alivisatos et al. and Nie et al., respectively. Since then, significant progress has been made, such as, advanced surface functional chemistry, the fabrication of near unity photoluminent quantum yields, the synthesis of heavy-metal-free quantum dots, and the commercialisation of quantum dot products. In this Special Issue, we focus on how quantum dots have been used to track the delivery of therapeutics in cells and in vivo. Drugs, and other therapeutics, can be targeted to specific cells, tissues, or both. In addition to passive uptake strategies, several triggered release mechanisms are being explored. Quantum dots have a role to play in tracking drugs, reporting uptake, indicating release events, and monitoring the effects of drugs on cells. This Special Issue is dedicated to the application of quantum dots in monitoring therapeutic delivery and efficacy.

Dr. Kevin Critchley
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Quantum dots

  • therapeutics

  • uptake

  • cellular tracking

  • in-vivo imaging

  • in-vitro assay

  • fluorescent reporters

Published Papers (1 paper)

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Research

Open AccessArticle Probing Temperature- and pH-Dependent Binding between Quantum Dots and Bovine Serum Albumin by Fluorescence Correlation Spectroscopy
Nanomaterials 2017, 7(5), 93; doi:10.3390/nano7050093
Received: 13 March 2017 / Revised: 15 April 2017 / Accepted: 21 April 2017 / Published: 25 April 2017
Cited by 1 | PDF Full-text (3342 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Luminescent quantum dots (QDs) with unique optical properties have potential applications in bio-imaging. The interaction between QDs and bio-molecules is important to the biological effect of QDs in vivo. In this paper, we have employed fluorescence correlation spectroscopy (FCS) to probe the temperature-
[...] Read more.
Luminescent quantum dots (QDs) with unique optical properties have potential applications in bio-imaging. The interaction between QDs and bio-molecules is important to the biological effect of QDs in vivo. In this paper, we have employed fluorescence correlation spectroscopy (FCS) to probe the temperature- and pH-dependent interactions between CdSe QDs with carboxyl (QDs-COOH) and bovine serum albumin (BSA) in buffer solutions. The results have shown that microscopic dissociation constant K′D is in the range of (1.5 ± 0.2) × 10−5 to (8.6 ± 0.1) × 10−7 M, the Hill coefficient n is from 0.4 to 2.3, and the protein corona thickness is from 3.0 to 9.4 nm. Variable-temperature measurements have shown both negative values of ∆H and ∆S for BSA adsorption on QDs-COOH, while pH has a profound effect on the adsorption. Additional, FCS measurement QDs-COOH and proteins in whole mice serum and plasma samples has also been conducted. Finally, simulation results have shown four favored QD binding sites in BSA. Full article
(This article belongs to the Special Issue Quantum Dots for Following Therapeutic Delivery)
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