Special Issue "Nanoparticles in Vivo and in Vitro Studies: A Collection of Parallel Approaches"
A special issue of Nanomaterials (ISSN 2079-4991).
Deadline for manuscript submissions: closed (31 October 2017)
Dr. Martin Wiemann
IBE R and D gGmbH, Institute for Lung Health, Mendelstrasse 11, D-48149 Münster, Germany
Phone: +49 251 9802340
Fax: +49 251 9802341
Interests: effects of (nano)particle and fibers on the lung; general particle toxicity on human and animal tissue; in vitro studies on cells to predict particle effects; macrophage biology
Within the last decade, thousands of scientific publications have investigated the biologic activity of nanoparticles using mammalian cell models and rodents for risk estimation. However, studies in which in vitro and in vivo experiments make use of essentially the same nanoparticles have been undertaken far less frequently, although a maximal degree of similarity between in vitro and in vivo approaches appears mandatory for a sound validation of in vitro results.
In this sense, the in vivo findings based on biokinetic behaviour of nanoparticles and on toxicological results should set out the frame for the design of predictive cell tests: Starting with the selection of most appropriate and representative test cells, meaningful cellular doses of nanoparticles appear most important, along with a fine-tuned experimental setting meant to unravel and understand the sophisticated response of cells upon nanoparticle treatment.
This Special Issue of Nanomaterials is therefore devoted to original contributions in which in vitro work is reasoned and accompanied by in vivo studies with the aim to maximize the degree of similarity of both approaches. Well-motivated studies aiming at the risk estimation for animals and humans are welcome and acceptance will not depend on the degree of success, as long as contributions are in accord with 3R principles.
Prof. Dr. Martin Wiemann
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- in vivo–in vitro comparison
- intratracheal instillation
- 3R principle
- validation study