Special Issue "Solid Phase Synthesis"

Guest Editor
Prof. Dr. Fernando Albericio
Institute for Research in Biomedicine (IRB Barcelona), Parc Científic de Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain
Website: http://www.pcb.ub.es/fama
E-Mail:
Phone: +34 93 403 70 88
Fax: +34 93 403 71 26
Interests: marine natural products; bioactive natural products; peptides; solid-phase chemistry; combinatorial chemistry; drug delivery systems

Guest Editor
Dr. Jan Spengler
Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, E-08028 Barcelona, Spain
E-Mail:
Interests: depsipeptides; peptide architectures; solid-phase chemistry; protecting groups; amino and hydroxy acids

Dear Colleagues,

Performing reactions in solid phase can speed up considerably the process of the preparation of organic compounds and libraries of their analogs, which is of special importance in drug discovery. However, the reactions usually require conditions different to those used in solution phase chemistry, and also specialized chemical tools. The objective of this issue will be to provide an overview on current investigation in the field of solid-phase synthesis, like the development and evaluation of new polymeric supports, linker, reagents, and also, the scope of chemical reactions in solid phase.

Prof. Dr. Fernando Albericio
Dr. Jan Spengler
Guest Editors

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• solid phase organic synthesis
• solid phase peptide synthesis
• polymeric supports
• linker
• immobilized reagents
• microwave reactions
• combinatorial chemistry

Title: Solid Phase Strategies for Standard and Modified Peptide Nucleic Acids (PNAs)
Authors: Tullia Tedeschi, Stefano Sforza, Roberto Corradini and Rosangela Marchelli
Affiliation: Dipartimento di Chimica Organica ed Industriale, Università di Parma, Via G.P. Usberti 17/A, 43100 Parma, Italy; E-Mail: tullia.tedeschi@unipr.it (T.T.)
Abstract: Almost 20 years ago Nielsen and coworkers presented for the first time Peptide Nucleic Acids (PNAs), a new class of molecules with the binding properties of DNA, but structuraly similar to peptides.
Since then, an always increasing number of pubblications have described different applications of PNAs in many fields, from biochemistry to biomedical science and diagnostics, by simply exploiting the ability of this molecule to bind complementary sequences of nucleic acids by standard Watson-Crick interactions. Since PNA monomer have an amino and a carboxy terminus, the PNA pseudopeptide backbone can be simply assembled by application of solid phase peptide synthesis protocols, with few modifications taking into account the peculiar PNA structure. Moreover, many modified PNAs have also been presented in these years, in some cases requiring suitable modifications to the solid phase synthetic procedures. As a consequence,also investigations concerning new chemical reactions on solid support for the synthesis of new PNA molecules bearing different functionalities also increased. This review explores the development of solid phase chemistries for the synthesis of standard and modified PNA with different chemical features