Special Issue "New Approaches to Counteract Drug Resistance in Cancer"
Deadline for manuscript submissions: closed (10 July 2016)
Prof. Dr. M. Helena Vasconcelos
FFUP – Faculdade de Farmácia da Universidade do Porto, Porto 4050-313, Potugal; I3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto 4200-135, Portugal
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Interests: cancer drug resistance; cancer multidrug resistance; intercellular transfer of drug resistance mediated by Extracellular Vesicles (EVs); new approaches to overcome drug resistance; drug-efflux pumps; escape from apoptosis; autophagy; metabolic alterations associated with drug resistance; tumour-microenvironment interactions; cancer stem cells; microRNAs; biomarkers of minimal residual disease and of drug resistance
Drug resistance in cancer, either intrinsic or acquired, is a major impediment to the success of cancer treatment. This clinical problem has proven very difficult to resolve, due to several factors, such as intratumor heterogeneity and tumor dynamics, together with the presence of cancer stem cells in tumors and the intercellular transfer of drug resistance mediated by extracellular vesicles (such as exosomes or microvesicles). This Special Issue of Molecules intends to collect state-of-the-art original research and review articles on new approaches to counteract drug resistance in cancer, which may include but are not exclusively limited to articles on: novel compounds or small molecules designed for drug targets responsible for drug resistance, compounds isolated from natural products with chemosensitizing effects, new RNAi therapeutics, based on antimiRs or siRNAs, designed towards targets responsible for drug resistance, or innovative drug delivery approaches to improve response to therapy. Articles on the development of new methods to detect resistance to antitumor drugs will also be considered.
Dr. Helena Vasconcelos
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- drug resistance
- multidrug resistance
- drug-efflux pumps
- ATP-binding cassette (ABC) transporters
- DNA repair
- tumor-microenvironment interactions
- cancer stem cells
- natural products
- small molecules
- synthesized compounds
- drug delivery