Special Issue "Targeted Drug Delivery and Nanocarriers"
Deadline for manuscript submissions: 10 April 2018
Prof. Sanjay Garg
Dr. Usha Y Nayak
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences (MCOPS), Manipal University, Manipal, Karnataka-576104, India
Website | E-Mail
Interests: controlled drug delivery; polymeric nanoparticles; liposomes; nanoemulsions; lipid nanoparticles; chronotherapeutics; solubility enhancement
Nanocarriers are widely explored systems for diagnostic and various drug delivery applications. Among the controlled drug delivery technologies, targeted drug delivery has attracted the attention of researchers, as it comprises the systemic delivery of the drug-carrier system to specific cell types, tissues, or organs. Multifunctional capabilities of nanocarriers make them suitable for the targeted delivery of drugs with diverse nature, including proteins, peptides, or DNA. Polymeric/lipid-based nanoparticles, nanocomposites, nanofibres, and carbon nanotubes are a few examples of nanocarriers which are used extensively. The surface of the nanoparticles is modified or conjugated with the suitable ligands for targetingin order to minimise the opsonization and to prolong the circulation time. Targeted nanoparticulate delivery would mainly be beneficial in diseases like cancer and diseases related to the brain.
In this Special Issue, articles are invited to provide a recent insight into the nanocarriers which are useful for targeted drug delivery.Prof. Sanjay Garg
Dr. Usha Y Nayak
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- dug delivery
- cancer therapy
- brain targeting
- lymphatic targeting
- hepatic targeting
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
- Type of the paper: Review
- Tentative title: Protein Nanocapsules for Antitumoral Therapy
- Authors: Maria Vallet-Regí, Alejandro Baeza, Maria Rocio Villegas
- Affiliation: Grupo de Investigación Biomateriales Inteligentes, GIBI-CIBER-BBN, Dept. of Chemistry in Pharmaceutical Sciences, Fac. Pharmacy-UCM, 28020 Madrid, Spain
- Title: Design and Efficacy of Polymer-based Nanocarriers for Brain Targeting
- Corresponding Author: B. A. Aderibigbe (firstname.lastname@example.org)
- Affiliation: Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape, South Africa.
- Abstract: The delivery of bioactive agent to the brain is hampered by the blood brain barrier. Several methods of administration of bioactive agents to the brain have been reported to be ineffective, unsafe and expensive. Polymer-based nanocarriers can penetrate the blood brain barrier with reduced side effects and are potential carriers for the delivery of bioactive agents to the brain. Their physicochemical properties play a major role in the brain uptake. This review provides a detailed information of the enhanced therapeutic effects, mechanisms and biological efficacy of polymer-based systems for the delivery of drugs to the brain.
- Keywords: nanocarriers; brain targeting; polymers; HIV; brain cancer
- Type of the paper: Review
- Tentative title: Intraperitoneal targeting of peritoneal carcinomatosis with tumor homing peptides
- Authors: Tambet Teesalu
- Affiliation: Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia
- Abstract: Peritoneal carcinomatosis (PC) - the metastatic spread of gynecologic, gastric, and colorectal cancers throughout the peritoneal cavity – is a serious clinical condition with an extremely poor prognosis. Compared to intravenous treatment regimens, intraperitoneal chemotherapy (IPC) can be used to improve therapeutic index of anticancer drugs: to achieve higher local concentration of the drug in the peritoneal malignant tissues and lower systemic exposure. To improve IPC further, it is desirable to develop strategies to extend drug retention time in the peritoneal cavity and to improve drug penetration into the peritoneal tumor nodules. In this review, we will describe preclinical development of active targeting strategies to improve IPC. We will focus on the use of tumor homing peptides to increase the peritoneal tumor binding and penetration of peritoneally-administered free and nanoformulated imaging agents and drugs for improved PC detection and treatment.