Special Issue "Macrocyclic Chemistry"


A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (30 November 2013)

Special Issue Editor

Guest Editor
Prof. Dr. Jurriaan Huskens
Molecular Nanofabrication Group, MESA+ Institute for Nanotechnology, University of Twente, TNW/MNF, PO Box 217, 7500AE Enschede, The Netherlands
Website: http://www.utwente.nl/tnw/mnf/People/academic_staff/prof_j_huskens/
E-Mail: j.huskens@utwente.nl
Phone: +31 53 4892995
Fax: +31 53 4894645
Interests: host-guest chemistry; cyclodextrins; multivalency; supramolecular surface chemistry; supramolecular materials; nanolithography; soft lithography

Special Issue Information

Dear Colleagues,

Macrocycles constitute the archetypical components of supramolecular chemistry. Many fundamental aspects of molecular recognition and supramolecular science have been and are being reveiled using macrocycles. From the start, both naturally occurring (e.g. cyclodextrins, porphyrins) as well as synthetic macrocycles (such as crown ethers, calixarenes, phthalocyanines) have been employed. Thermodynamic phenomena such as the chelate effect, multivalency and cooperativity, have been and still are topics of thorough investigation. Synthetic procedures have been developed in order to create macrocycles, such as high-dilution synthesis and template-directed synthesis, and to functionalize them in order to introduce functional groups at one or more positions selectively and/or to control the conformation of the macrocycle. Macrocycles are applied in ion and molecular sensing, metal ion protection in biomedical imaging, treatment of heavy metal waste streams, drug delivery and increase of drug efficacy, and many, many others. Modern topics of investigation encompass dynamic covalent chemistry with macrocycles to provide evolutionary amplification of optimal receptors, the design of vehicles for drug and gene delivery, and receptor-functionalized platforms as models for cell membrane interactions. These examples show that macrocylic chemistry is still and will remain a vibrant area of chemistry for the foreseeable future!

This special issue of Molecules welcomes previously unpublished manuscripts covering all aspects of natural and synthetic macrocycles including their design, synthesis, functionalization, molecular recognition, and applications.

Prof. Dr. Jurriaan Huskens
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).


  • macrocycles
  • macrocyclization
  • template synthesis
  • host-guest recognition
  • cation and anion recognition
  • neutral molecule recognition

Published Papers (8 papers)

Molecules 2014, 19(2), 2261-2285; doi:10.3390/molecules19022261
Received: 24 December 2013; in revised form: 29 January 2014 / Accepted: 7 February 2014 / Published: 21 February 2014
Show/Hide Abstract | PDF Full-text (1628 KB) | HTML Full-text | XML Full-text
abstract graphic

Molecules 2014, 19(1), 550-567; doi:10.3390/molecules19010550
Received: 2 December 2013; in revised form: 23 December 2013 / Accepted: 24 December 2013 / Published: 3 January 2014
Show/Hide Abstract | PDF Full-text (765 KB) | HTML Full-text | XML Full-text | Supplementary Files
abstract graphic

Molecules 2013, 18(10), 12687-12706; doi:10.3390/molecules181012687
Received: 29 July 2013; in revised form: 13 September 2013 / Accepted: 29 September 2013 / Published: 14 October 2013
Show/Hide Abstract | PDF Full-text (2164 KB)

Molecules 2013, 18(9), 10514-10530; doi:10.3390/molecules180910514
Received: 18 June 2013; in revised form: 24 August 2013 / Accepted: 27 August 2013 / Published: 30 August 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (991 KB) | Supplementary Files
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Molecules 2013, 18(6), 6230-6268; doi:10.3390/molecules18066230
Received: 3 April 2013; in revised form: 15 May 2013 / Accepted: 20 May 2013 / Published: 24 May 2013
Show/Hide Abstract | Cited by 2 | PDF Full-text (1200 KB)

Molecules 2013, 18(5), 4972-4985; doi:10.3390/molecules18054972
Received: 26 March 2013; in revised form: 16 April 2013 / Accepted: 24 April 2013 / Published: 26 April 2013
Show/Hide Abstract | Cited by 1 | PDF Full-text (1705 KB) | Supplementary Files
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Molecules 2013, 18(4), 4328-4341; doi:10.3390/molecules18044328
Received: 12 March 2013; in revised form: 2 April 2013 / Accepted: 9 April 2013 / Published: 12 April 2013
Show/Hide Abstract | Cited by 6 | PDF Full-text (504 KB) | Supplementary Files
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Molecules 2013, 18(3), 3168-3182; doi:10.3390/molecules18033168
Received: 18 February 2013; in revised form: 7 March 2013 / Accepted: 7 March 2013 / Published: 11 March 2013
Show/Hide Abstract | PDF Full-text (364 KB)

Last update: 15 July 2013

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