E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Special Issue "Heterocycles in Supramolecular Chemistry"

Quicklinks

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (31 October 2011)

Special Issue Editor

Guest Editor
Prof. Dr. Wim Dehaen (Website)

Department of Chemistry, Celestijnenlaan 200F, B-3001 Leuven, Belgium
Phone: +32 16 32 74 39
Fax: +32 16 32 79 90
Interests: organic synthesis; heterocycles; supramolecular chemistry; porphyrin analogues; natural products; helicenes

Keywords

  • molecular recognition
  • hydrogen bonding
  • macrocycles
  • sensing
  • switches
  • membrane transport

Published Papers (2 papers)

View options order results:
result details:
Displaying articles 1-2
Export citation of selected articles as:

Research

Open AccessArticle Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations
Molecules 2014, 19(7), 9736-9759; doi:10.3390/molecules19079736
Received: 4 June 2014 / Revised: 25 June 2014 / Accepted: 2 July 2014 / Published: 8 July 2014
Cited by 10 | PDF Full-text (708 KB) | HTML Full-text | XML Full-text
Abstract
Robust chemical routes towards valuable bioactive entities such as riboflavines, quinoxalinones and benzodiazepines are described. These make use of modern flow hydrogenation protocols enabling the chemoselective reduction of nitro group containing building blocks in order to rapidly generate the desired amine intermediates [...] Read more.
Robust chemical routes towards valuable bioactive entities such as riboflavines, quinoxalinones and benzodiazepines are described. These make use of modern flow hydrogenation protocols enabling the chemoselective reduction of nitro group containing building blocks in order to rapidly generate the desired amine intermediates in situ. In order to exploit the benefits of continuous processing the individual steps were transformed into a telescoped flow process delivering selected benzodiazepine products on scales of 50 mmol and 120 mmol respectively. Full article
(This article belongs to the Special Issue Heterocycles in Supramolecular Chemistry)
Figures

Open AccessArticle Synthesis, Metal Ion Complexation and Computational Studies of Thio Oxocrown Ethers
Molecules 2011, 16(10), 8670-8683; doi:10.3390/molecules16108670
Received: 17 August 2011 / Revised: 29 September 2011 / Accepted: 11 October 2011 / Published: 14 October 2011
Cited by 3 | PDF Full-text (343 KB)
Abstract
The synthesis of some thio-oxocrown ether ligands, B1 (1,4-dithio-12-crown-4), B2 (1,7-dithio-12-crown-4), B3 (1,7-dithio-15-Crown-5), B4 (1,7-dithio-18-crown-6), B5 (1,10-dithio-18-crown-6), B6 (1,10-dithio-21-crown-7), under mild conditions, were reported. The ligands were characterized by FT-IR, 1H NMR and GC-MS spectroscopy. The formation of 1:1 ligand complexes [...] Read more.
The synthesis of some thio-oxocrown ether ligands, B1 (1,4-dithio-12-crown-4), B2 (1,7-dithio-12-crown-4), B3 (1,7-dithio-15-Crown-5), B4 (1,7-dithio-18-crown-6), B5 (1,10-dithio-18-crown-6), B6 (1,10-dithio-21-crown-7), under mild conditions, were reported. The ligands were characterized by FT-IR, 1H NMR and GC-MS spectroscopy. The formation of 1:1 ligand complexes with a variety of metal salts (Ag+, Ca+2, K+, Na+, Mg+2, Zn+2 and Fe+2) were investigated by a conductometric method in a 1:1 dioxane–water system at 25 °C, and the complexation constants (Ke = (ΛMAm -Λ) / ((Λ-ΛMaΛbAm) [L]) and free energy (∆Go= - RT lnKe) values are calculated. Details of the specific molecular interactions between the ligands and metals were proposed. We also performed DFT calculations to explain their geometrical properties, charges and frontier molecular orbitals. Full article
(This article belongs to the Special Issue Heterocycles in Supramolecular Chemistry)

Journal Contact

MDPI AG
Molecules Editorial Office
St. Alban-Anlage 66, 4052 Basel, Switzerland
molecules@mdpi.com
Tel. +41 61 683 77 34
Fax: +41 61 302 89 18
Editorial Board
Contact Details Submit to Molecules
Back to Top