Special Issue "Gas Phase Reactions"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (30 June 2013)
Prof. Dr. Dietmar A. Plattner
Manuscript Submission Information
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The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Review
Title: “Solid/gas Biocatalysis, an Efficient Tool for Fundamental Studies on Enzyme Activity and Selectivity”
Authors: M. Graber, A. Mensi, N. Fniter, B. Belkhiria and Z. Marton
Affiliations: UMR 7266 CNRS-ULR, LIENSS, LIttoral ENvironnement SociétéS, Université de La Rochelle, Pôle Sciences et Technologie, Bâtiment Marie Curie, Avenue Michel Crépeau, 17042 La Rochelle, France
Abstract: From the middle of the 1980s, it was demonstrated that solid–gas biocatalysis was possible with enzymes usually acting on liquid substrates, with several examples of enzyme in the dry state acting on gaseous substrates. Different isolated enzymes were tested successfully such as the horse liver dehydrogenase, the Sulfolobus solfataricus dehydrogenase, the Pischia pastoris alcohol oxidase, the baker’s yeast alcohol dehydrogenase and lipolytic enzymes. This opened a new research area that led to the definition of new continuous cleaner processes for single or multi steps biotransformations, involving either enzymatic solid–gas bioreactors or microbial set-ups.
Since solid–gas bioreactors allow control and independent variation of the thermodynamic activity of substrates and other added components, they offer the possibility to modulate and to study the effect of each component present in the microenvironment of the biocatalyst. Therefore these solid–gas systems constitute an efficient tool to understand and rationalize the effects of the microenvironment of an enzyme on its activity, selectivity and stability.
In this review, some examples of the benefits of this thermodynamic approach and control of enzymatic reactions are discussed, and an overview of some applications of solid–gas technology to fundamental studies related to the influence of the microenvironment on enzymes are given.