Special Issue "Recent Advances in Flow Chemistry"
Deadline for manuscript submissions: closed (15 August 2016)
Dr. Kerry Gilmore
Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Potsdam-Golm Science Park, D-14424 Potsdam, Germany
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Interests: Development of chemical assembly systems for the production of small molecules and pharmaceuticals, mechanistic investigations, development of new flow techniques/technologies
Over the past 20 years, continuous chemistry has emerged as an effective means to conduct chemical syntheses, both at the micro- and meso-scale, providing an improved product quality and safety as well as being accompanied by a lowered environmental impact when compared to traditional batch syntheses. Flow chemistry offers two distinct advantages over the respective batch processes: control and connectivity. Precise control over reaction conditions, in particular reaction time, mixing, heat transfer, and irradiation window, has allowed for a wide range of chemistries either not possible or extremely inefficient in batch. With the ability to connect several flow reactors in series, elegant multi-step syntheses have been accomplished, producing high value compounds and active pharmaceutical ingredients. Due to large increases in surface area, biphasic reactions are significantly accelerated within the confines of a flow system. While not all encompassing, flow chemistry has proven to be facilitating in the studying and performing a wide range of chemical reactions encompassing biochemistry, materials, polymers, mechanistic studies, and elegant multistep organic syntheses. This Special Issue of Molecules welcomes submissions of research articles covering both micro- and mesoflow reactions dealing with selectivity, catalysis, photochemistry, multi-step synthesis, the development of new reactions, and other related subjects.
Dr. Kerry Gilmore
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Photochemistry in flow
- Packed-bed reactors
- Continuous, multi-step synthesis
- Flash chemistry
- Biphasic transformations
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Authors: Tobias Illg 1,*, Annett Knorr 2,† and Lutz Fritzsche 2,†
Affiliation: 1 Fraunhofer ICT‐IMM, 55129 Mainz, Carl‐Zeiss‐Straße 18‐20, Germany; E‐Mail:firstname.lastname@example.org
2 BAM Federal Institute for Materials Research and Testing , 12205 Berlin, Unter den Eichen 87,
Germany; E‐Mails: email@example.com (A.K.); firstname.lastname@example.org (L.F.)
† These authors contributed equally to this work.
Author to whom correspondence should be addressed; E‐Mail: email@example.com;Tel.: +49‐6131‐990‐335; Fax: +49‐6131‐990‐205.
Abstract: The synthesis of peroxycarboxylic esters, as one subgroup of organic peroxides, is characterized by a high thermal hazard potential regarding process safety. In case of failure in the production process, e.g., if the heat of reaction cannot be removed sufficiently fast, the decomposition reaction can be triggered. In consequence remarkable amounts of heat and gas can be released and can cause a high extent of damage. Multifarious technical and organizational measures are necessary to organize the industrial production of peroxides safely. With the introduction of micro reaction technology plenty of possibilities have been opened to carry out highly exothermic reactions in smaller volumes and with more efficient heat removal. In this paper we report the application of three different microstructured reactors, representing different mixing strategies, to synthesize two peroxymonocarboxylic esters, namely tert‐Butyl peroxypivalate and tert‐Butyl peroxy‐2‐ethylhexanoate. The following reactor types were considered: an orifice microreactor, a split and recombine microreactor and a capillary tube reactor in combination with ultrasonication. The efficiency of the two phase liquid/liquid reaction is expressed in comparison of conversion and selectivity. With micro reaction technology a remarkable increase in space‐time‐yield, ranging from 6,200 kgm‐3 h‐1 to 414.000 kgm‐3 h‐1, is achieved.