Special Issue "Diels-Alder Reaction"


A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (31 December 2012)

Special Issue Editor

Guest Editor
Prof. Dr. Raymond J. Giguere
Department of Chemistry, Skidmore College, 815 N. Broadway, Saratoga Springs, NY 12866, USA
Website: http://cms.skidmore.edu/chemistry/faculty/giguere.cfm
E-Mail: rgiguere@skidmore.edu
Interests: intramolecular cycloadditions; microwave heating in organic synthesis; public perception of natural science

Special Issue Information

Dear Colleagues,

The Diels-Alder reaction, discovered in 1928, is widely recognized as one of the cornerstone synthetic organic reactions of the 20th century. In fact, it is one of the most commonly employed reactions for the synthesis of natural products, as well as for the rapid construction of cyclic and polycyclic compounds. The intramolecular extension of the Diels-Alder, first reported by Kurt Alder in 1952, led the way to a significant number of elegant synthetic achievements. Further historical developments (e.g., Lewis acid catalysis, frontier orbital theory, introduction of heteroatoms, comprehension of stereoelectronic features, solvent and temperature effects, the use of high pressure or microwave heating conditions, etc.) involving this Nobel-prize winning reaction have made the Diels-Alder reaction an efficient, reliable and powerful tool in the hands of synthetic chemists everywhere.

Molecules Special Issue on Diels-Alder chemistry will provide a timely venue for presenting key developments and important facets of this milestone reaction. I strongly encourage authors to submit papers for this Special Issue, and am hopeful that the topics published will assist in promoting novel applications of this exceptional process for the synthesis of organic molecules of interest and importance.

Prof. Raymond J. Giguere, 
Guest Editor


  • Diels-Alder Reaction
  • Hetero Diels-Alder
  • IMDA
  • cycloaddition
  • [4 + 2]
  • diene
  • dienophile
  • endo
  • exo

Published Papers (4 papers)

Molecules 2013, 18(6), 6969-6989; doi:10.3390/molecules18066969
Received: 1 March 2013; in revised form: 14 May 2013 / Accepted: 30 May 2013 / Published: 14 June 2013
Show/Hide Abstract | Download PDF Full-text (497 KB)
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Molecules 2013, 18(2), 2243-2254; doi:10.3390/molecules18022243
Received: 25 December 2012; in revised form: 20 January 2013 / Accepted: 5 February 2013 / Published: 13 February 2013
Show/Hide Abstract | Download PDF Full-text (576 KB)
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Molecules 2012, 17(11), 13687-13703; doi:10.3390/molecules171113687
Received: 18 September 2012; in revised form: 8 November 2012 / Accepted: 12 November 2012 / Published: 20 November 2012
Show/Hide Abstract | Download PDF Full-text (454 KB) |  Supplementary Files

Molecules 2012, 17(8), 8795-8803; doi:10.3390/molecules17088795
Received: 13 June 2012; in revised form: 26 June 2012 / Accepted: 10 July 2012 / Published: 25 July 2012
Show/Hide Abstract | Download PDF Full-text (380 KB) | Download XML Full-text |  Supplementary Files
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Last update: 4 March 2014

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