Special Issue "Dendrimers - from Synthesis to Applications"

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A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: 29 February 2012

Special Issue Editor

Guest Editor
Prof. Dr. Afang Zhang
Department of Polymer Materials, Shanghai University, Chengzhong Street 20, Shanghai 201800, China
Website: http://www.mse.shu.edu.cn/Default.aspx?tabid=11073&ctl=Detail&mid=23586&Id=45304&SkinSrc=[L]Skins/mat-en_con/mat-en_con
E-Mail:
Phone: +41 44 633 1390

Published Papers

Click here to see a list of 7 papers that have been published in this special issue.

Special Issue Information

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.

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Keywords

biomedical applications
chiral dendrimer
dendrimer assembly
dendrimer block copolymers
dendrimer chirality
dendrimer conjugates
dendrimer-like star polymers
dendrimer MRI contrast agents
dendrimer nanoparticles
dendrimer nonreactors
dendrimer nano-templates
dendrimer synthesis
dendron
dendronized polymers
drug delivery
hyperbranched polymers
organocatalysis
peptide dendrimer
stimuli-responsive dendrimers
supramolecular dendrimers

Planned Papers

Type of Paper: Review
Title: Solution NMR Studies of Dendrimers (Outline)
Authors: Minghui Chai ^1,* and Peter L. Rinaldi ^2,*
Affiliations: ¹Department of Chemistry, Central Michigan University, Mt. Pleasant, MI 48858; E-mail: Minghui.chai@cmich.edu
²Department of Chemistry, The University of Akron, Akron, OH 44325; E-mail: PeterRinaldi@uakron.edu
Abstract: NMR spectroscopy has been a powerful tool for structural characterization and property study of molecules, especially for biopolymers. Dendrimers are unique type of synthetic macromolecules with a cascade hyper-branched structure and spherical shape if perfectly generated. Classic 1D 1H and 13C NMR techniques have been heavily utilized for dendrimer structural verification after the synthesis. This review focuses on the applications of special NMR techniques such as NMR relaxation time and diffusion measurements, multinuclear NMR spectroscopy, as well as multidimensional homo- and hetero-nuclear correlation spectroscopy for studying the structure, property and interactions of dendrimers.
Keywords: dendrimer; dendrimer assembly; NMR; multinuclear NMR; multidimensional NMR

Type of Paper: Article

Title: Influence of Dendrimer Chemistry on its Antiprion Activity

Authors: Barbara Klajnert ^1,*, Ling Peng ², Rafael Gomez ^3,5,F. Javier de la Mata ^3,5, M. Angeles Muñoz-Fernandez ^4,5, Maria Bryszewska ¹

Affiliations: ¹Department of General Biophysics, University of Lodz, Poland
²Departement de chimie CNRS, Marseille, France
³ Departamento de Química Inorgánica, Universidad de Alcalá, Spain
⁴ Hospital General Universitario Gregorio Marañón, Madrid, Spain

⁵ CIBER-BBN
* Author to whom correspondence should be addressed; E-mail: aklajn@biol.uni.lodz.pl

Abstract: Prion disorders are fatal neurodegenerative diseases resulting in the formation of fibrils – amyloid-like structures.It has been shown that dendrimers possess antiprion activity. We checked different dendrimers in terms of generation (size) and chemical composition: carbosilane dendrimers with tertiary and quaternary amino groups on the surface and PAMAM dendrimers with the same functionalities. It turned out that dendrimer interior and end groups influenced fibril formation. For PAMAM dendrimers at low concentrations we observed the acceleration of fibril formation, whereas high concentrations completely inhibited the process. In the case of carbosilane dendrimers no acceleration was observed, but the inhibitory trend occurred for higher concentrations.

Figure 1. Kinetics of fibril formation in the presence of dendrimers that inhibited the process, and upon adding dendrimers that enhanced the fibril formation.

abstract graphic

Type of Paper: Review
Title: Fluorescence Studies of the Host Properties of Dendrimers
Author: Brian Wagner
Affiliation: Department of Chemistry, University of Prince Edward Island Charlottetown, PE C1A 4P3, Canada; E-Mail: bwagner@upei.ca
Abstract: Dendrimers represent an interesting and unique class of organic host molecules. Fluorescence spectroscopy provides a sensitive and useful technique for studying the formation of supramolecular host-guest inclusion complexes by dendrimer hosts. Non-fluorescent dendrimer host properties can be studied by using polarity-sensitive fluorescent probes as guests. In the case of dendrimers with fluorescent groups as part of the core or branch structure, or as appended end groups, the host properties can be studied for any guest. In addition to the use of fluorescence to study the fundamental properties of host-guest systems, such fluorescent dendrimer-based inclusion systems have applications as fluorescent sensors.

Last update: 19 September 2011

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