Special Issue "Advances in Medicinal Chemistry of Antibiotics"

Guest Editor
Prof. Dr. Françoise Van Bambeke
Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Avenue Mounier 73 B1.73.05, 1200 Brussels, Belgium
E-Mail: francoise.vanbambeke@uclouvain.be
Phone: +32 2 764 73 78
Fax: +32 2 764 73 73
Interests: new antibiotics; pharmacokinetics and pharmacodynamics; intracellular infection; efflux transporters

Dear Colleagues,

In a world of increasing resistance, we have to urgently come with new, potent, weapons. Discovery of novel antibiotic classes acting on still unexploited targets remains a challenge. Another approach that has been followed quite intensively and successfully over the last years consists in refining our knowledge of structure-activity relationships to come with molecules showing an increased intrinsic activity, a reduced susceptibility to resistance mechanisms, an improved safety profile, or a better pharmacokinetic profile.
This special issue is aimed at presenting up-to-date reviews or promising experimental data on structure-activity relationships, either for existing classes of antibiotics or for new classes of antibiotics (meaning for which there is still no drug on the market).

Prof. Dr. Françoise Van Bambeke
Guest Editor

Submission

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• structure-activity relationships
• antibiotics
• new antibacterial targets
• activity towards multiresistant bacteria