Special Issue "Advances in Carbohydrate Chemistry 2015"
Deadline for manuscript submissions: 15 January 2015
Dr. Vito Ferro
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia
Interests: carbohydrate chemistry; medicinal chemistry; heparanase inhibitors; heparan sulfate mimetics
Dr. Trinidad Velasco-Torrijos
Department of Chemistry, National University of Ireland, Maynooth, Co. Kildare, Ireland
Interests: carbohydrate chemistry; glycoconjugates; glycopeptides; glycolipids; glycomimetics, molecular scaffolds
Since the launch of the first Special Issue in this journal on Advances in Carbohydrate Chemistry, the field of glycobiology has continued to grow and mature. It is well established that carbohydrates (or glycans) play critical roles in biological systems in both normal physiology and disease. However, a better understanding of the intricate details of carbohydrate–protein interactions is the key to unlocking the enormous potential of glycans and glycomimetics for the development of new therapeutics, vaccines and diagnostics. Carbohydrate chemists can continue to play an important role in advancing our understanding of glycobiology by providing the required synthetic access to pure, well-defined carbohydrates and glycoconjugates for biological studies, although many challenges still remain. In addition, carbohydrates and glycomimetics have potential applications in many areas of biomedical research and drug development. Finally, carbohydrates remain an excellent source of building blocks for chiral pool syntheses and as raw materials for the development of biotechnologically derived commodity chemicals.
We invite our colleagues to submit research articles and comprehensive reviews addressing the above mentioned topics, and on recent advances in carbohydrate chemistry in general, for publication in this Special Issue.
Dr. Vito Ferro
Dr. Trinidad Velasco-Torrijos
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
- carbohydrate chemistry
- molecular scaffolds
- sustainable carbohydrate raw materials
- carbohydrate nanostructures
- bioactive compounds
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: The synthesis of nonulosonic acids using a [6 + 3] aldol condensation approach
Authors: James Carter and Milton J. Kiefel
Affiliations: Institute for Glycomics, Griffith University (Gold Coast campus)
Abstract: Nonulosonic acids are 9-carbon acidic sugars that are found as components of glycans in a range of organisms, including mammals and bacteria. One member of this family are the sialic acids like N-acetyl neuraminic acid, which is well known to be intimately involved in a number of human diseases. Less well studied are the pseudaminic acids and legionamininc acids, although it is know that these sugars play an important role in bacterial virulence. Whilst much is known regarding the biosynthesis of these important sugars, the efficient synthesis of analogues of nonulosonic acids remains a considerable challenge. This mini-review will bring together what has been reported regarding the synthesis of nonulosonic acids using an aldol condensation between simple hexose sugars and a 3-carbon building block, and will highlight the strengths and weaknesses of the different strategies employed.
Last update: 24 July 2014