Special Issue "Biocatalysis and Biotransformations in Organic Synthesis"
QuicklinksA special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (20 September 2012)
Special Issue Editor
Guest Editor
Dr. Ioulia Smonou
Department of Chemistry, University of Crete, Campus Voutes-Heraklion, 71003 Crete, Greece
Website: http://www.chemistry.uoc.gr/organic/pdf/Smonou_CV.pdf
E-Mail: smonou@chemistry.uoc.gr
Interests: biocatalysis-biotransformations in organic synthesis; asymmetric synthesis of bioactive compounds using biocatalytic methods; applied biocatalysis; mechanisms of organic reactions
Special Issue Information
Dear Colleagues,
The contribution of Biocatalysis and Biotransformations in Organic Synthesis (BBOS) is of increasing importance and reflects the emerging challenge of the academic community and the chemical industry towards green chemistry. The design and development of more efficient synthetic processes is one of the major goals of green chemistry. Moreover, the integration of biocatalysis into chemical processes and the innovative potential of biotransformations in the promotion of the multistep catalytic concept, can contribute to the significantly improved process economy by avoiding time-, effort-, and solvent intensive steps. This innovative methodology offers great applications on Sustainable Chemistry.
This Special Issue on Biocatalysis and Biotransformations in Organic Synthesis will offer an attractive forum to present the synthetic potential of biocatalysis. I strongly encourage authors to submit papers for this Special Issue on BBOS, within the scope of Molecules. I hope that the topics covered will reflect the potential and the excitement of BBOS in the chemical community.
Ioulia Smonou
Guest Editor
Submission
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs) and starting from 1 July 2012, it is 1600 CHF.
Keywords
- Biocatalysis
- Enzymatic reactions
- Biotransformations
- Chemoenzymatic synthesis
- Enantioselective synthesis
- Cascade chemoenzymatic processes
- Multi-step one-pot processes
- New biocatalytic processes
- Sustainable Chemistry
- Multistep enzymatic transformations
Published Papers (3 papers)
 Molecules 2012, 17(8), 8955-8967; doi:10.3390/molecules17088955
Received: 24 April 2012; in revised form: 27 June 2012 / Accepted: 3 July 2012 / Published: 26 July 2012
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Molecules 2012, 17(11), 13045-13061; doi:10.3390/molecules171113045
Received: 26 September 2012; in revised form: 15 October 2012 / Accepted: 30 October 2012 / Published: 2 November 2012
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Molecules 2012, 17(12), 13813-13824; doi:10.3390/molecules171213813
Received: 17 September 2012; in revised form: 15 November 2012 / Accepted: 16 November 2012 / Published: 22 November 2012
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Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Use of Free Saccharomyces Cerevisiae Yeasts in the Chemoselective Bioreduction of (1E,4E)-1,5-Bis(4-methoxyphenyl)-1,4-pentadien-3-one in Biphasic System
Authors: César A. Schaefer 1, Vanessa D. Silva 1, Boris U. Stambuk 2 and Maria G. Nascimento 1
Affiliations: 1 Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, 88040-900, Brazil
2 Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, 88040-900, Brazil
Abstract: This article describes the chemoselective bioreduction of (1E,4E)-1,5-Bis(4-methoxyphenyl)-1,4-pentadien-3-one (1) mediated by baker’s yeast (BY, Saccharomyces cerevisiae) in aqueous/n-hexane biphasic system. The biotransformation of this compound was chemoselective and formed only the corresponding saturated ketone 1,5-Bis(4-methoxyphenyl)-3-pentanone (2). The influence of various factors that may influence on the bioreduction, such as addiction of co-solvents and percentage of co-solvent, using six different yeast of S. cerevisiae (four commercial and two industrial), substrate and yeast concentration, temperature, pH, volume of aqueous and organic phases were investigated. The best reaction conditions were 66,7 g L-1 of BY from Fleischmann, 8,3 mM of substrate, pH 6.5 at 35 ºC in the presence of 2,5 % of DMSO as an additive, and Vaq/Vorg of 30/30. Under these conditions, the product 2 was recovered with conversions of 74 and 100% in 5 h and 24 h, respectively.
Last update: 18 May 2012