Special Issue "The Functions of the Microbiome in Skin Health and Disease"
A special issue of Microorganisms (ISSN 2076-2607).
Deadline for manuscript submissions: 31 March 2019
Dr. Emma Barnard
David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Interests: Propionibacterium acnes, bacteriophage, probiotics, acne vulgaris, skin microbiome
Dr. Andrew McDowell
Northern Ireland Centre for Stratified Medicine, University of Ulster, Londonderry BT47 6SB, UK
Website | E-Mail
Phone: +44 (0) 2890 972097
Interests: medical microbiology; bacterial pathogens; gram positive; propionibacteria; acne; medical device infection; genome sequencing; sequence analysis; bacterial evolution; molecular systematics; bacterial taxonomy; phylogenetics; genetic population analysis; typing; MLST
The skin plays an important role in protecting the body from invasion of foreign materials and harmful pathogens. One of the mechanisms by which the skin can perform this role is through the activities and interactions of the resident bacterial, fungal, and viral species. Commensal microbes are essential to skin health but, on occasion, the same microorganism conferring a health benefit can also lead to a diseased state when their abundances and activities change or when the environmental conditions become less favorable as a result of alterations in the host. In this Special Issue, we highlight the roles of beneficial skin organisms in protecting against colonization and infection of pathogens, guiding the host immune system, and discuss their functional changes and interactions with the host in response to environmental changes.
Dr. Emma Barnard
Dr. Andrew McDowell
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- skin microbiome
- skin probiotics
- atopic dermatitis
- skin health
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: The role of Propionibacterium acnes in acne vulgaris and progressive macular hypomelanosis: insights from genetic population analysis and whole genome sequencing
Authors: Andrew McDowell and Emma Barnard
Abstract: The anaerobic bacterium Propionibacterium acnes is believed to play an important role in the pathophysiology of the skin diseases acne vulgaris and progressive macular hypomelanosis (PMH). Over the last 10 years our understanding of the taxonomic and intraspecies diversity of this bacterium has increased tremendously, and with it the realisation that particular lineages are associated with skin health while others appear related to disease. This review will highlight and discuss our current knowledge of the phylogenetic and genetic population structure of this bacterium within the skin microbiome, the association of specific clonal complexes and sequence types with acne and PMH, and differences between phylogroups at the genomic and proteomic level that may help to explain host interactions and the potential role of certain lineages in the pathophysiology of these skin conditions.
Title: Pre/probiotic like products targeting microbiome to decrease skin symptoms after cleanser
Authors: Audrey GUENICHE, team LOREAL
Abstract: For more than 150 years, to be healthy, we have protected ourselves from the bacterial world. The perceptions of this have, in the last 15 years inverted, and we now begin to get rid of the hygienist dogma thanks to the published scientific works: bacteria / fungi begin to be revered and to do well.
It has been shown that the skin microbiota limits adhesion of pathogen microorganisms, contributes to reinforce innate immunity, modulates inflammation and strengthens the skin barrier function, participates to wound healing, skin barrier recovery. Thus it is very easy to understand that its disequilibrium contributes to skin disorders. Topical skin cleansers are commonly used products to clean the skin. To investigate the time needed for skin and its microbiota to recover, a group of 30 healthy volunteers were selected. Instrumental evaluation including skin hydration, barrier function and pH are altered just after cleansing and recover within few hours’. Clinical expert evaluation and self-assessment revealed that a harsh wash increases dryness, roughness and discomfort and these skin alterations do not recover even after few hours. The harsh wash decreased the quantity, diversity and changes the community structure of the skin bacterial communities and skin bacteria are not at all recovered after even after few hours. Knowing these important findings, we found that a dedicate skin care product is able to help the skin microbiota and facilitate its quick recovery. What is really interesting is that the complete skin bacteria recovery is earlier than the complete decrease of roughness and discomfort, underlining that Bacteria might be a key player of skin recovery