Special Issue "Metabolomic Studies of the Human Gut Microbiome"
A special issue of Metabolites (ISSN 2218-1989).
Deadline for manuscript submissions: closed (30 November 2014)
Despite tremendous advances in characterizing the microbial diversity within the gastrointestinal tract, very little is known about the function and role of even the most dominant bacterial species within the human host. It is becoming widely accepted that the metabolic products formed by gut bacteria directly impact on human health and disease, particularly regarding immune response and inflammation. Emerging evidence suggests that these metabolites play an important role in the development of many diseases including diabetes, cardiovascular disease and cancer. In most cases, the products of metabolism are uncharacterized and their mechanism of action unknown. This Special Issue of Metabolites “Metabolomic Studies of the Human Gut Microbiome” will be dedicated to areas of research, which use metabolomic methodologies to establish the link between microbial diversity and metabolic functionality. The topics that will be covered by this Special Issue will be those that address identifying microbial metabolites, particularly at their in vivo concentrations, establishing their mechanism of formation and the bacterial species responsible. Metabolites produced by both commensal and pathogenic gut bacteria will be of interest, as will the gut-derived systemic metabolites. There will be a focus on aspects that influence the microbial metabotype, including; genetic factors, diet, BMI, physical activity, non-dietary xenobiotics (e.g. drugs, pollutants), oxidative stress, aging and disease.
Dr. Wendy Roslyn Russell
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed Open Access quarterly journal published by MDPI.
- microbial communities
- quantitative metabolomics
- microbial-derived gut metabolites
- microbial-derived systemic metabolites
- metabolic modelling
- LC-MS, GC-MS and NMR
- multivariate analysis; data integration