Special Issue "Surface Modification and Assembly of Magnetic Nanoparticle Materials"

Guest Editor
Dr. Erik Reimhult
ETH Zurich, Department of Materials, HCI F 537, Laboratory for Surface Science and Technology, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich, Switzerland
Website: http://www.surface.mat.ethz.ch/people/senior_scientists/erikr
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Phone: +41 44 633 75 47
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Interests: functional biointerfaces; biosensors; supported lipid bilayers; biomimetic membrane sensing; functional nanoparticles; parallel nanopatterning techniques

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Title: Efficacy and Durability in Direct Labelling of Mesenchymal Stem Cell Using Ultrasmall Superparamagnetic Iron Oxide Nanoparticles with Silica, Dextran, and PEG Coatings
Authors: Yi-Xiang J. Wang ², Thibault Quercy-Jouvet ^1,3, Hao-Hao Wang ², Ak-Wai Li ¹, Chun-Pong Chak ¹, Shouhu Xuan ¹, Lin Shi ², De-Feng Wang ², Siu-Fung Lee ¹, Ping-Chung Leung ³, Clara B. S. Lau ³, Kwok-Pui Fung ³ and Ken Cham-Fai Leung ¹
Affiliations: ¹ Center of Novel Functional Molecules and Institute of Molecular Functional Materials, Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China; E-Mail: cfleung@cuhk.edu.hk (K.C.-F.L.)
² Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong , Shatin, NT, Hong Kong SAR, China
³ Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
Abstract: We herein report a comparative study of mesenchymal stem cell (MSC) labelling using spherical superparamagnetic iron oxide (SPIO) nanoparticles that composed of different coatings, namely, silica, dextran, and poly(ethylene glycol) (PEG). These nanomaterials possess a similar SPIO core size of 6–7 nm. Together with their coatings, the overall sizes are 10–15 nm for all SPIO@SiO₂, SPIO@dextran, and SPIO@PEG nanoparticles. These nanoparticles were investigated for their efficacies to be uptaken by rabbit bone marrow-derived MSCs without any transfecting agent. Experimentally, both SPIO@SiO₂ and SPIO@PEG nanoparticles could be successfully uptaken by MSCs while the SPIO@dextran nanoparticles demonstrated limited labelling efficiency. The durability of SPIO@SiO₂ and SPIO@PEG nanoparticles in MSCs after three weeks of culture were compared by Prussian blue staining tests. Generally, SPIO@SiO₂ nanoparticles demonstrated higher blueness than SPIO@PEG nanoparticles, rendering them better materials for MSCs labelling by a direct uptake when durable intracellullar retention of SPIO is desired.